A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 20446-20451. PMID: 19074283, PMCID: PMC2629334, DOI: 10.1073/pnas.0810372105.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Toll-like receptorsType II IFNImmune responseNucleic acid-sensing Toll-like receptorsReceptor 3Innate antiviral immune responseAntiviral innate immune responseTLR3-deficient miceType I IFN responseAntiviral immune responseAntiviral innate immunityInnate immune responseI IFN responseInnate antiviral immunityType II interferonAcute myocarditisVirus infectionAntiviral immunityI IFNMouse resistanceInnate immunityTypes of virusesIFN responseIFN