Featured Publications
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelBioenergetic capacityMitochondrial DNATranscriptional upregulationCyclic GMP-AMP synthaseGMP-AMP synthaseTranscriptional regulationBioenergetic organellesFunctional mitochondriaMitochondrial membraneExternal mitochondrial membraneAnabolic pathwaysMitochondrial massAnion channelInterferon genesHSC transdifferentiationSubsequent activationCGAS-STINGTransdifferentiationIRF3 pathwayPathwaySTING pathwayGenesMitochondriaQuiescent HSCs
2011
Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation
Ouyang X, Zhang R, Yang J, Li Q, Qin L, Zhu C, Liu J, Ning H, Shin MS, Gupta M, Qi CF, He JC, Lira SA, Morse HC, Ozato K, Mayer L, Xiong H. Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nature Communications 2011, 2: 314. PMID: 21587231, PMCID: PMC3112536, DOI: 10.1038/ncomms1311.Peer-Reviewed Original ResearchConceptsTh17 cell differentiationRegulatory factor familyTranscription factor IRF8T cell-specific deletionCritical roleFunctional diversityLineage commitmentTranscription factorsCell-specific deletionFactor familyTranscriptional inhibitorIRF8 geneMolecular mechanismsCell differentiationConventional knockoutIRF8IRF8 deficiencyPhysical interactionDifferentiationTh17 cellsPathogenesis of autoimmunityCellsGenesUnique subsetDiversity
2008
Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt
Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H. Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt. European Journal Of Immunology 2008, 38: 1204-1214. PMID: 18412165, PMCID: PMC2989250, DOI: 10.1002/eji.200838145.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell DifferentiationForkhead Transcription FactorsGene ExpressionGene Expression RegulationInterferon-gammaInterleukin-17InterleukinsListeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMinor Histocompatibility AntigensNuclear Receptor Subfamily 1, Group F, Member 3OvalbuminReceptors, Antigen, T-CellReceptors, Retinoic AcidReceptors, Thyroid HormoneSpleenT-LymphocytesT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaConceptsIL-17IL-22Th17 cellsIL-27Spleen cellsRORgamma tEpstein-Barr virus-induced gene 3IL-17-producing cellsReduced bacterial loadIL-35Protective immunityIL-12p35Th17 conditionsAdaptive immunityEBI3Mouse studiesL. monocytogenesBacterial loadMiceElevated levelsAcute challengeGene 3High levelsP28Immunity
2006
SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T. SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells. Journal Of Cellular Physiology 2006, 207: 428-436. PMID: 16419040, DOI: 10.1002/jcp.20579.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsBone Morphogenetic Protein 6Bone Morphogenetic ProteinsCell DifferentiationCell LineCell SurvivalChlorocebus aethiopsCOS CellsGene ExpressionLeupeptinsMiceMuscle Fibers, SkeletalMyoblastsMyoD ProteinMyogeninOsteoblastsOsteocalcinPhosphorylationProtein Kinase InhibitorsProto-Oncogene Proteins c-junSmad ProteinsSuppressor of Cytokine Signaling ProteinsTransfectionUp-RegulationConceptsC2C12 cellsJunB protein expressionSOCS-2Mesenchymal precursorsMyotube formationSmad-responsive reporter geneUbiquitin-proteasome pathwayCOS-7 cellsProtein expressionKey transcriptional factorBMP/SmadPrecursor cell lineSuppressor of cytokineGrowth hormone signalingSOCS familyCell fateHormone signalingTranscriptional activationBone morphogenic proteinAcceleration of proliferationTranscriptional levelReporter geneTranscriptional factorsNuclear accumulationJunB protein