2020
Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction
Wang S, Su X, Xu L, Chang C, Yao Y, Komal S, Cha X, Zang M, Ouyang X, Zhang L, Han S. Glycogen synthase kinase-3β inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction. Journal Of Molecular And Cellular Cardiology 2020, 149: 82-94. PMID: 32991876, DOI: 10.1016/j.yjmcc.2020.09.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCARD Signaling Adaptor ProteinsEnzyme ActivationFibroblastsGlycogen Synthase Kinase 3 betaIndolesInflammasomesInflammationMaleMaleimidesMyocardial InfarctionMyocardial IschemiaMyocytes, CardiacNLR Family, Pyrin Domain-Containing 3 ProteinProtein Kinase InhibitorsProtein MultimerizationRats, Sprague-DawleyVascular RemodelingConceptsNLRP3 inflammasome activationGSK-3β inhibitionMyocardial infarctionInflammasome activationNOD-like receptor family pyrin domainGSK-3βFamily pyrin domainGlycogen synthase kinase-3β inhibitionCardiac dysfunctionMyocardial dysfunctionCardiac damageHeart dysfunctionHeart diseaseSterile inflammationInflammatory responseRat modelDay 2Pyrin domainCardiac fibroblastsSuccessful inductionHypoxia treatmentDysfunctionGSK-3 activityHuman cardiomyocytesInflammasome stimulation
2006
SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T. SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells. Journal Of Cellular Physiology 2006, 207: 428-436. PMID: 16419040, DOI: 10.1002/jcp.20579.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsBone Morphogenetic Protein 6Bone Morphogenetic ProteinsCell DifferentiationCell LineCell SurvivalChlorocebus aethiopsCOS CellsGene ExpressionLeupeptinsMiceMuscle Fibers, SkeletalMyoblastsMyoD ProteinMyogeninOsteoblastsOsteocalcinPhosphorylationProtein Kinase InhibitorsProto-Oncogene Proteins c-junSmad ProteinsSuppressor of Cytokine Signaling ProteinsTransfectionUp-RegulationConceptsC2C12 cellsJunB protein expressionSOCS-2Mesenchymal precursorsMyotube formationSmad-responsive reporter geneUbiquitin-proteasome pathwayCOS-7 cellsProtein expressionKey transcriptional factorBMP/SmadPrecursor cell lineSuppressor of cytokineGrowth hormone signalingSOCS familyCell fateHormone signalingTranscriptional activationBone morphogenic proteinAcceleration of proliferationTranscriptional levelReporter geneTranscriptional factorsNuclear accumulationJunB protein