Featured Publications
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. Cell Reports 2021, 37: 109968. PMID: 34758326, PMCID: PMC8667589, DOI: 10.1016/j.celrep.2021.109968.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseProgression of NAFLDLineage-restricted deletionFatty liver diseaseMultiple mRNA transcriptsMyeloid cell activationDiet-induced developmentMethyladenosine (m<sup>6</sup>A) RNA modificationMRNA metabolismProtein methyltransferaseLiver diseaseRNA modificationsCellular stressMetabolic reprogrammingDDIT4 mRNACell activationObesityDifferential expressionMammalian targetMRNA transcriptsSignificant downregulationCytokine stimulationPathway activityMetabolic phenotypeMRNA levels
2022
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. RNA m6A demethylase ALKBH5 regulates the development of γδ T cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2203318119. PMID: 35939687, PMCID: PMC9388086, DOI: 10.1073/pnas.2203318119.Peer-Reviewed Original ResearchConceptsDemethylase ALKBH5Messenger RNAΓδ T cellsΓδ T cell biologyCommon posttranscriptional modificationΓδ T cell developmentT cell biologyT cell developmentCell precursorsT cell precursorsMammalian cellsRNA modificationsPosttranscriptional modificationsTissue homeostasisCell biologyT cellsTarget genesCheckpoint roleCell developmentM6A demethylase ALKBH5ALKBH5Γδ T-cell originΓδ T cell repertoireCell populationsEarly development
2009
IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor–Initiated Apoptosis via Repression of FLICE-like Protein Expression
Yang D, Wang S, Brooks C, Dong Z, Schoenlein PV, Kumar V, Ouyang X, Xiong H, Lahat G, Hayes-Jordan A, Lazar A, Pollock R, Lev D, Liu K. IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor–Initiated Apoptosis via Repression of FLICE-like Protein Expression. Cancer Research 2009, 69: 1080-1088. PMID: 19155307, PMCID: PMC2633427, DOI: 10.1158/0008-5472.can-08-2520.Peer-Reviewed Original ResearchAnimalsApoptosisCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 8Caspase InhibitorsCell Line, TumorEnzyme ActivationFas Ligand ProteinHumansImmunohistochemistryInterferon Regulatory FactorsMiceMitochondriaReceptors, TNF-Related Apoptosis-Inducing LigandRNA, MessengerRNA, Small InterferingSarcomaSarcoma, ExperimentalTNF-Related Apoptosis-Inducing Ligand
2001
Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
Ouyang X, Takahashi K, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells. Journal Of Pharmacological Sciences 2001, 87: 289-296. PMID: 11829148, DOI: 10.1254/jjp.87.289.Peer-Reviewed Original ResearchConceptsCultured neonatal rat cardiac cellsAng IIRat cardiac cellsNeonatal rat cardiac cellsCardiac cellsHypertrophic responseSalvia miltiorrhizaImmediate early response gene expressionAng II actionAng II stimulationChronotropic responsivenessAngiotensin IIMorphological injuryDose-dependent cytotoxicityII stimulationProtective effectEarly response gene expressionDifferent pharmacological activitiesEthyl acetate insoluble fractionResponse gene expressionTanshinone IIAHypertrophic growthPharmacological activitiesCardiomyocytesEffective constituents