Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury
Feng X, Lu TC, Chuang PY, Fang W, Ratnam K, Xiong H, Ouyang X, Shen Y, Levy DE, Hyink D, Klotman M, D'Agati V, Iyengar R, Klotman PE, He JC. Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury. Journal Of The American Society Of Nephrology 2009, 20: 2138-2146. PMID: 19608706, PMCID: PMC2754106, DOI: 10.1681/asn.2008080879.Peer-Reviewed Original ResearchConceptsHIV-associated nephropathyPodocyte differentiation markersSTAT3 phosphorylationDevelopment of HIVANPathogenesis of HIVANHIV-1 transgenic miceSTAT3 activityReduced expressionHIV-1 transgeneDifferentiation markersExpression of VEGFTg26 miceKidney injuryTubulointerstitial injuryActivation of STAT3Tubulointerstitial compartmentHIV-1 NefTransgenic miceB cell developmentProliferation markersPodocyte proliferationHuman kidneyMiceSTAT3 target genesPrimary podocytes