2023
Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnisotropyCytokinesDiffusion Tensor ImagingHumansMiddle AgedReflexSchizophreniaWhite MatterConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanism
2021
Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia
Zhou Y, Huang J, Zhang P, Tong J, Fan F, Gou M, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yang F, Tian B, Tian L, Savransky A, Hare S, Ryan MC, Goldwaser E, Chiappelli J, Chen S, Kochunov P, Kvarta M, Tan Y, Hong LE. Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia. Schizophrenia Bulletin 2021, 47: 1048-1057. PMID: 33501486, PMCID: PMC8266595, DOI: 10.1093/schbul/sbaa196.Peer-Reviewed Original ResearchConceptsHigher allostatic loadCognitive deficitsCortical thicknessCortical thinningAllostatic loadCholesterol levelsSchizophrenia patientsLow high-density lipoprotein cholesterolHypersensitive C-reactive proteinHigh-density lipoprotein cholesterolLower total cholesterol levelsDiastolic blood pressureTotal cholesterol levelsC-reactive proteinWaist-hip ratioLeft superior frontal gyrusHigh cholesterol levelsMean cortical thicknessHigher heart rateSuperior frontal gyrusEarly intervention strategiesGray matter integrityNormoweight patientsLipoprotein cholesterolBlood pressure
2020
Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Hong L, Tan Y. Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study. Neuroscience Letters 2020, 742: 135548. PMID: 33279570, DOI: 10.1016/j.neulet.2020.135548.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaRight postcentral gyrusInferior frontal gyrusPostcentral gyrusSchizophrenic patientsWhole brain resting-state functional connectivity (rsFC) analysisMotor circuitsLeft primary motor cortexRight supplementary motor areaFunctional connectivityPathogenesis of TDResting-state fMRI studyResting-state functional connectivity analysisFrontal gyrusAIMS total scoreLeft triangular partPrimary motor cortexAbnormal functional connectivityRight superior parietal lobuleSupplementary motor areaNegative Syndrome ScaleNon-TD groupSuperior parietal lobuleBilateral parietal cortexAltered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study
Liang S, Xue K, Wang W, Yu W, Ma X, Luo S, Zhang J, Sun X, Luo X, Liu F, Zhang Y. Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study. Psychiatry Research Neuroimaging 2020, 303: 111134. PMID: 32652482, DOI: 10.1016/j.pscychresns.2020.111134.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug-naïve major depressive disorderAltered brain functionFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMDD patientsDepressive disorderDefault mode networkBrain functionClinical featuresFunctional impairmentHealthy subjectsLow-frequency fluctuation (ALFF) valuesDrug-naïve MDD patientsResting-state fMRI studyAssessment Short TestTotal FAST scoresALFF valuesNeurocognitive impairmentPatientsConsensus Cognitive BatteryLingual gyrusOccupational functioningFAST scoreGlobal functioning
2019
Transcriptome-wide piRNA profiling in human gastric cancer
Lin X, Xia Y, Hu D, Mao Q, Yu Z, Zhang H, Li C, Chen G, Liu F, Zhu W, Shi Y, Zhang H, Zheng J, Sun T, Xu J, Chao HH, Zheng X, Luo X. Transcriptome-wide piRNA profiling in human gastric cancer. Oncology Reports 2019, 41: 3089-3099. PMID: 30896887, PMCID: PMC6448102, DOI: 10.3892/or.2019.7073.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsTransposable elementsHuman gastric cancerProtein-coding genesNon-coding RNAsCancer risk SNPsPiRNA expressionNearest geneWhole transcriptomeCancer stem cellsDNA variantsIndefinite capacityDifferential expressionAdjacent non-tumorous tissuesStem cellsHuman stomachRegulatory effectsGenesRNANon-tumorous tissuesExpressionMolecular featuresBiological systemsGastric cancerTranscriptome
2018
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement
Yu T, Li Y, Fan F, Cao H, Luo X, Tan S, Yang F, Zhang X, Shugart YY, Hong LE, Li CR, Tan Y. Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement. Scientific Reports 2018, 8: 12884. PMID: 30150749, PMCID: PMC6110787, DOI: 10.1038/s41598-018-31186-y.Peer-Reviewed Original ResearchConceptsGray matter volumeAbnormal Involuntary Movement ScaleTardive dyskinesiaMatter volumeTD severityAntipsychotic medication treatmentCerebral morphological changesAbnormal involuntary movementsBrain structural magnetic resonance imagesPsychopathological symptomsNegative Syndrome ScaleNon-TD groupVoxel-based morphometryMedication treatmentHealthy controlsGMV changesMotor disordersAIMS scoresInvoluntary movementsMovement ScaleStructural magnetic resonance imagesTemporal cortexSchizophrenia patientsLingual gyrusSyndrome ScaleResting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe
Zhang P, Li Y, Fan F, Li CR, Luo X, Yang F, Yao Y, Tan Y. Resting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe. Neuroscience 2018, 385: 237-245. PMID: 29909076, DOI: 10.1016/j.neuroscience.2018.06.014.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleMiddle occipital gyrusRight calcarine sulcusTardive dyskinesiaBrain activity changesClinical parametersLeft middle occipital gyrusSchizophrenic patientsCalcarine sulcusOccipital lobeSeverity of TDAIMS total scoreDecreased brain activityFractional amplitudeResting-state functional magnetic resonance imaging (fMRI) dataResting-state brain activityLow-frequency fluctuationsNegative Syndrome ScaleBrain activityActivity changesConstructional scoresTD groupTD patientsHealthy controlsMagnetic resonance imaging dataPrincipal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults
Wang K, Liu Y, Ouedraogo Y, Wang N, Xie X, Xu C, Luo X. Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults. Journal Of Psychiatric Research 2018, 100: 113-120. PMID: 29518578, PMCID: PMC6329582, DOI: 10.1016/j.jpsychires.2018.02.022.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug useEarly alcoholDepressive disorderOdds ratioAdult major depressive disorderMultiple logistic regression analysisConfidence intervalsMultiple logistic regressionLogistic regression analysisOverall prevalenceTobacco useUS adultsSignificant associationLogistic regressionRegression analysisNational surveyDisordersAdultsPotential factorsScoresAssociationTobaccoYearsPast year
2017
Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol
Chen Y, Xu C, Harirforoosh S, Luo X, Wang KS. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal Of Psychiatric Research 2017, 96: 65-72. PMID: 28987514, PMCID: PMC6195678, DOI: 10.1016/j.jpsychires.2017.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCerebellumCholesterolComputer SimulationFamilyGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiddle AgedNeoplasmsPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2ConceptsRisk of ADRisk of cancerAlzheimer's diseaseAAO of ADSingle nucleotide polymorphismsTotal cholesterol levelsMultiple logistic regressionLDL cholesterolTotal cholesterolCholesterol levelsAD patientsCancer riskMultiple linear regression analysisLinear regression analysisNeuropsychiatric disordersLogistic regressionDiseaseCancerWilcoxon testExpression levelsRiskRegression analysisGene expression levelsHuman brainGenetic variantsCorrelation between cytochrome P450 2C19 genetic polymorphism and treatment response to escitalopram in panic disorder
He Q, Yuan Z, Liu Y, Zhang J, Yan H, Shen L, Luo X, Zhang Y. Correlation between cytochrome P450 2C19 genetic polymorphism and treatment response to escitalopram in panic disorder. Pharmacogenetics And Genomics 2017, 27: 279-284. PMID: 28614176, DOI: 10.1097/fpc.0000000000000290.Peer-Reviewed Original ResearchFamily-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease
Wang KS, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Journal Of Neuroimmunology 2017, 310: 60-65. PMID: 28778446, PMCID: PMC6167010, DOI: 10.1016/j.jneuroim.2017.06.010.Peer-Reviewed Original ResearchConceptsRisk of ADAlzheimer's diseaseSingle nucleotide polymorphismsAAO of ADHuman brain regionsNervous system developmentApoE expressionOnset (AAO) of ADBrain regionsDiseaseSignificant expressionRiskMarker analysisGenetic variantsAssociationFamily-based association analysisHaplotype analysisPresent studyEquation statisticsAgeFirst studyOnsetFamily-based associationFamily-based sampleExpressionReduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
Zhu Y, Tang Y, Zhang T, Li H, Tang Y, Li C, Luo X, He Y, Lu Z, Wang J. Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder. BMC Psychiatry 2017, 17: 48. PMID: 28152990, PMCID: PMC5288938, DOI: 10.1186/s12888-016-1146-5.Peer-Reviewed Original ResearchConceptsFunctional connectivityBilateral precuneusSubscale scoresRight precuneusSPD groupSeed-based functional connectivity methodPersonality disorderDecreased functional connectivityAltered functional connectivityRight superior temporal gyrusChinese versionSCL-90 scoresResting-state scanSuperior temporal gyrusSchizophrenia spectrum disordersSchizotypal personality disorderFunctional connectivity methodsHealthy controlsRight parahippocampusParahippocampusSymptom ChecklistBiological markersTemporal gyrusConclusionsOur findingsPrecuneus
2016
SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression
Huang T, Ji Y, Hu D, Chen B, Zhang H, Li C, Chen G, Luo X, Zheng XW, Lin X. SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression. Oncotarget 2016, 5: 80990-81002. PMID: 27835598, PMCID: PMC5348371, DOI: 10.18632/oncotarget.13167.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell Transformation, ViralComputational BiologyDatabases, GeneticEpstein-Barr Virus InfectionsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHerpesvirus 4, HumanHost-Pathogen InteractionsHumansMaleMiddle AgedReal-Time Polymerase Chain ReactionRNA, Long NoncodingRNA, MessengerRNA, NeoplasmSequence Analysis, RNAStomach NeoplasmsYoung AdultConceptsEpstein-Barr virusGastric cancerAdjacent normal tissuesGastric carcinomaNormal tissuesPossible candidate biomarkersHigh mortality rateAdjacent tissue samplesVariety of cancersCancer-specific pathwaysLncRNA-mRNA co-expression networkNormal human tissuesEpstein-BarrReal-time PCRLong non-coding RNAsIndependent cohortMortality rateCandidate biomarkersCancerMRNA expressionSNHG8Tissue samplesTumorigenesis mechanismsHuman cancersBody mapBDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls.
Zhang XY, Chen da C, Tan YL, Tan S, Luo X, Zuo L, Soares JC. BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls. The Journal Of Clinical Psychiatry 2016, 77: e1011-8. PMID: 27561148, DOI: 10.4088/jcp.15m10269.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHealthy controlsCognitive functionBDNF gene variantsCase-control studyBDNF genetic variantsBDNF gene polymorphismPathogenesis of schizophreniaCognitive performanceRBANS total scoreHan Chinese populationBDNF polymorphismVal66Met polymorphismNeurotrophic factorBDNF geneGene polymorphismsCognitive impairmentPatientsPotential associationChinese populationNeuropsychological StatusHan Chinese individualsRepeatable BatterySchizophreniaTotal scoreAssociation of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjectsThe symptom trajectories to clinical remission in Chinese patients with unipolar major depressive disorder
Cao Y, Shen J, Li W, Zhang Y, Guo X, Li C, Zhang Y, Luo X. The symptom trajectories to clinical remission in Chinese patients with unipolar major depressive disorder. Asia-Pacific Psychiatry 2016, 8: 309-311. PMID: 27015764, PMCID: PMC5035708, DOI: 10.1111/appy.12240.Peer-Reviewed Original ResearchConceptsClinical remissionChinese patientsSymptom trajectoriesUnipolar major depressive disorderMajor depressive disorder symptomsWeeks of assessmentMajor depressive disorderTreatment of fluoxetineDepressive disorder symptomsDepressive disorderTreatment responseProminent symptomWeek 1Psychomotor retardationRemissionSymptom severityPatientsDisorder symptomsFluoxetineSymptomsSeverityWeeksTreatmentOutpatientsShow heterogeneityCHRNA4 was associated with prepulse inhibition of schizophrenia in Chinese: a pilot study
Shi J, Wang Z, Tan Y, Fan H, An H, Zuo L, Yang F, Tan S, Li J, Zhang X, Zhou D, Luo X. CHRNA4 was associated with prepulse inhibition of schizophrenia in Chinese: a pilot study. Cognitive Neuropsychiatry 2016, 21: 156-167. PMID: 26982087, DOI: 10.1080/13546805.2016.1155437.Peer-Reviewed Original ResearchConceptsMs prepulse intervalsSingle nucleotide polymorphismsAuditory startle reflexCentral nervous systemPotential endophenotypePrepulse intervalsPrepulse inhibitionSensorimotor gatingTT genotypeGG genotypeNervous systemStartle reflexSchizophreniaPilot studyPPI levelsCHRNA4PatientsNucleotide polymorphismsCurrent studyIndependent replicationInhibitionEndophenotypesLow levelsPPIPolymorphismPsychometric Properties of Prodromal Questionnaire-Brief Version among Chinese Help-Seeking Individuals
Xu L, Zhang T, Zheng L, Li H, Tang Y, Luo X, Sheng J, Wang J. Psychometric Properties of Prodromal Questionnaire-Brief Version among Chinese Help-Seeking Individuals. PLOS ONE 2016, 11: e0148935. PMID: 26859774, PMCID: PMC4747512, DOI: 10.1371/journal.pone.0148935.Peer-Reviewed Original ResearchConceptsProdromal Questionnaire-Brief VersionClinical high riskHelp-seeking individualsProdromal QuestionnaireHelp-seeking outpatientsPreliminary epidemiological studyLogistic regression modelsPsychometric propertiesOutpatient clinicPresent studyCHR subjectsProdromal individualsHigh riskEpidemiological studiesPsychotic diagnosesPositive diagnosisSIPS diagnosesDistress scoresProdromal SyndromesConcordant validityPsychosisDiagnosisTotal scoreOutpatient sampleCutoff score
2015
BDNF polymorphisms are associated with schizophrenia onset and positive symptoms
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with schizophrenia onset and positive symptoms. Schizophrenia Research 2015, 170: 41-47. PMID: 26603468, DOI: 10.1016/j.schres.2015.11.009.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPositive symptomsBDNF gene variantsCase-control studyBDNF gene polymorphismClinical symptom severityPathophysiology of schizophreniaNegative Syndrome ScaleHan Chinese populationBDNF polymorphismNeurotrophic factorBDNF geneSchizophrenia onsetGene polymorphismsSyndrome ScalePotential associationChinese populationSymptom severityHan Chinese individualsSymptomsPatientsSchizophreniaGene variantsPsychopathological symptomsChinese individualsGenetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations
Wang KS, Zuo L, Pan Y, Xie C, Luo X. Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. Journal Of Psychiatric Research 2015, 71: 1-7. PMID: 26522866, DOI: 10.1016/j.jpsychires.2015.09.008.Peer-Reviewed Original ResearchConceptsAlcohol dependenceSingle nucleotide polymorphismsMultiple logistic regression analysisMarshfield sampleRisk of obesityLogistic regression analysisCentral nervous systemGenetic variantsObesityNervous systemCommon genetic variantsAlcohol addictionCaucasian populationRegression analysisPLINK softwareGenetic associationV geneFirst evidenceAssociationCaucasian samplesGenetic componentPopulation