2023
A significant, functional and replicable risk KTN1 variant block for schizophrenia
Mao Q, Lin X, Yin Q, Liu P, Zhang Y, Qu S, Xu J, Cheng W, Luo X, Kang L, Taximaimaiti R, Zheng C, Zhang H, Wang X, Ren H, Cao Y, Lin J, Luo X. A significant, functional and replicable risk KTN1 variant block for schizophrenia. Scientific Reports 2023, 13: 3890. PMID: 36890161, PMCID: PMC9995530, DOI: 10.1038/s41598-023-27448-z.Peer-Reviewed Original Research
2022
Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariates
2020
KTN1 variants and risk for attention deficit hyperactivity disorder
Luo X, Guo X, Tan Y, Zhang Y, Garcia‐Milian R, Wang Z, Shi J, Yu T, Ji J, Wang X, Xu J, Zhang H, Zuo L, Lu L, Wang K, Li C. KTN1 variants and risk for attention deficit hyperactivity disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2020, 183: 234-244. PMID: 32190980, PMCID: PMC7210069, DOI: 10.1002/ajmg.b.32782.Peer-Reviewed Original ResearchSignificant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence
Luo X, Guo X, Luo X, Tan Y, Zhang P, Yang K, Xie T, Shi J, Zhang Y, Xu J, Zuo L, Li C. Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. Addiction Biology 2020, 26: e12888. PMID: 32115811, PMCID: PMC7641293, DOI: 10.1111/adb.12888.Peer-Reviewed Original Research
2013
Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence
Zuo L, Wang K, Wang G, Pan X, Zhang X, Zhang H, Luo X. Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence. American Journal On Addictions 2013, 23: 411-414. PMID: 24961364, PMCID: PMC4111256, DOI: 10.1111/j.1521-0391.2013.12115.x.Peer-Reviewed Original ResearchRare SERINC2 variants are specific for alcohol dependence in individuals of European descent
Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics And Genomics 2013, 23: 395-402. PMID: 23778322, PMCID: PMC4287355, DOI: 10.1097/fpc.0b013e328362f9f2.Peer-Reviewed Original ResearchNKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent
Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug And Alcohol Dependence 2013, 129: 254-264. PMID: 23455491, PMCID: PMC3628730, DOI: 10.1016/j.drugalcdep.2013.02.006.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesExpression quantitative loci (eQTL) analysisGene regionMetabolic pathwaysQuantitative loci analysisSNP-expression associationsCis-acting regulatory effectsDiscovery sampleSNP-disease associationsNumerous genesReplication sampleLocus analysisAssociation studiesAssociation analysisRisk SNPsTranscript expressionSNPsRegulatory effectsGenesPathwayEuropean descentExpressionAssociation of rare PTP4A1-PHF3-EYS variants with alcohol dependence
Zuo L, Zhang X, Deng HW, Luo X. Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence. Journal Of Human Genetics 2013, 58: 178-179. PMID: 23324950, DOI: 10.1038/jhg.2012.153.Peer-Reviewed Original Research
2011
A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study
Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X. A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study. PLOS ONE 2011, 6: e26726. PMID: 22096494, PMCID: PMC3210123, DOI: 10.1371/journal.pone.0026726.Peer-Reviewed Original Research
2003
CALCYON gene variation, schizophrenia, and cocaine dependence
Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J. CALCYON gene variation, schizophrenia, and cocaine dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 125B: 25-30. PMID: 14755439, DOI: 10.1002/ajmg.b.20092.Peer-Reviewed Original ResearchConceptsCocaine dependenceSingle nucleotide polymorphismsExact testEA subjectsFisher's exact testSubstance use disordersCalcyon geneDopamine receptor-interacting proteinsComparison of alleleUse disordersEuropean-American subjectsControl groupAA subjectsSchizophreniaReceptor-interacting proteinHaplotype frequenciesPotential roleSpecific polymorphismsMotor controlGene variationSame haplotype blockGenetic variantsSubjectsNucleotide polymorphismsLinkage disequilibrium