2013
Genome-wide association studies of maximum number of drinks
Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, Wang W, Zuo L, Wang KS. Genome-wide association studies of maximum number of drinks. Journal Of Psychiatric Research 2013, 47: 1717-1724. PMID: 23953852, PMCID: PMC4286179, DOI: 10.1016/j.jpsychires.2013.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol-Related DisordersAustraliaCase-Control StudiesCocaine-Related DisordersCommunity Health PlanningFamily HealthFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideTobacco Use DisorderWhite PeopleConceptsGenome-wide association studiesSingle nucleotide polymorphismsGenes/regionsAustralian twin-family studyAssociation studiesFirst genome-wide association studyGene discoveryAlcohol consumption phenotypeFamily sampleAddiction geneticsConsumption phenotypesAlcoholism (COGA) sampleDDC geneCaucasian samplesContinuous phenotypesMaxDrinksSage samplesPhenotypeIntermediate phenotypesGenesSignificant associationAlcohol dependence
2008
Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample
Zuo L, Kranzler HR, Luo X, Yang BZ, Weiss R, Brady K, Poling J, Farrer L, Gelernter J. Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample. Neuropsychopharmacology 2008, 34: 1504-1513. PMID: 19052543, PMCID: PMC2879626, DOI: 10.1038/npp.2008.206.Peer-Reviewed Original ResearchBlack or African AmericanCase-Control StudiesCluster AnalysisCocaineCocaine-Related DisordersFamilyGenetic Predisposition to DiseaseHaplotypesHumansLinkage DisequilibriumParanoid DisordersPolymorphism, Single NucleotideReceptor, Cannabinoid, CB1Regression AnalysisSequence Analysis, DNAUnited StatesWhite People
2007
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry 2007, 13: 531-543. PMID: 17622222, PMCID: PMC3163084, DOI: 10.1038/sj.mp.4002035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismCase-Control StudiesCocaine-Related DisordersEuropeExonsFemaleGenetic Predisposition to DiseaseHaplotypesHeroin DependenceHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Opioid, deltaReceptors, Opioid, kappaRiskSubstance-Related DisordersUnited StatesConceptsLogistic regression analysisSingle nucleotide polymorphismsRegression analysisTag single nucleotide polymorphismsOPRD1 variantsG alleleC alleleDrug dependenceSignificant associationRisk effectsEuropean AmericansStratification artifactSignificant differencesPositive associationHaplotypic associationsMultiple testingAssociationOPRK1OPRD1Dependence riskSD
2003
CALCYON gene variation, schizophrenia, and cocaine dependence
Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J. CALCYON gene variation, schizophrenia, and cocaine dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 125B: 25-30. PMID: 14755439, DOI: 10.1002/ajmg.b.20092.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanCocaine-Related DisordersGenetic VariationHaplotypesHumansLinkage DisequilibriumMembrane ProteinsPolymorphism, Single NucleotideSchizophreniaConceptsCocaine dependenceSingle nucleotide polymorphismsExact testEA subjectsFisher's exact testSubstance use disordersCalcyon geneDopamine receptor-interacting proteinsComparison of alleleUse disordersEuropean-American subjectsControl groupAA subjectsSchizophreniaReceptor-interacting proteinHaplotype frequenciesPotential roleSpecific polymorphismsMotor controlGene variationSame haplotype blockGenetic variantsSubjectsNucleotide polymorphismsLinkage disequilibriumHaplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans
Luo X, Kranzler HR, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 120B: 97-108. PMID: 12815747, DOI: 10.1002/ajmg.b.20034.Peer-Reviewed Original ResearchAlcoholismBlack PeopleCocaine-Related DisordersExonsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muSubstance-Related DisordersUnited StatesWhite People