2014
Genome‐wide association discoveries of alcohol dependence
Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang X, Vanderlinden LA, Tabakoff B, Luo X. Genome‐wide association discoveries of alcohol dependence. American Journal On Addictions 2014, 23: 526-539. PMID: 25278008, PMCID: PMC4187224, DOI: 10.1111/j.1521-0391.2014.12147.x.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide levelPotential biological functionsGWAS samplesADH clusterGenome-wide association discoveryRisk variantsBiological functionsAlcohol dehydrogenase clusterWide significant associationsRobust risk locusCis-eQTLsRisk lociNrd1Association studiesKIAA0040PKNOX2RNA expressionImportant roleHTR7Replicable associationsIndividual samplesSERINC2Mouse brainVariants
2004
Genomic regions controlling corticosterone levels in rats
Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Genomic regions controlling corticosterone levels in rats. Biological Psychiatry 2004, 55: 634-641. PMID: 15013833, DOI: 10.1016/j.biopsych.2003.11.005.Peer-Reviewed Original ResearchConceptsGenomic regionsQuantitative trait locus (QTL) analysisGenome-wide levelSpecific genomic regionsUnderstanding of susceptibilitySignificant QTLGenomic backgroundChromosome 4Locus analysisF2 progenyGenetic differencesSuggestive significanceDisease susceptibilityQTLFirst identificationCongenic animalsDeoxyribonucleic acidGenetic factorsProgenyIdentificationRegionSusceptibilityLevels