2023
RNA m6A methylation in psychiatric disorders.
Mao Q, Luo J, Luo X, Zhu X, Wang K, Zuo L, Zhang Y, Luo X. RNA m6A methylation in psychiatric disorders. EC Psychology And Psychiatry 2023, 12 PMID: 38145106, PMCID: PMC10745284.Peer-Reviewed Original ResearchMajor psychiatric disordersPsychiatric disordersM6A modificationM6A methyltransferase METTL3Synaptic protein synthesisInflammatory infiltrationImmune infiltrationRNA m6A methylationTherapeutic targetM6A regulatorsAlzheimer's diseaseNeuropsychiatric disordersMethyltransferase METTL3Subtype classificationPromising targetDiseaseDisordersM6A methylationInfiltrationCritical roleProtein synthesisReviewPathogenesisComprehensive reviewPreventionSpatial Multiomics Analysis in Psychiatric Disorders.
Mao Q, Huang S, Luo X, Liu P, Wang X, Wang K, Zhang Y, Chen B, Luo X. Spatial Multiomics Analysis in Psychiatric Disorders. EC Psychology And Psychiatry 2023, 12: 1-5. PMID: 37424930, PMCID: PMC10328214.Peer-Reviewed Original ResearchPsychiatric disordersAlzheimer's diseaseCommon psychiatric disordersCertain brain regionsRisk genesMiddle temporal gyrusMultiomics analysisAutism spectrum disorderAD pathologyDisease progressionOlfactory bulbSpectrum disorderMouse modelPsychiatric diseasesHuman hippocampusBrain regionsNeuropsychiatric disordersTemporal gyrusLiterature searchAid diagnosisDisordersTranscriptional signatureDiseaseHippocampusSpatial transcriptomic analysis
2018
Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults
Wang K, Liu Y, Ouedraogo Y, Wang N, Xie X, Xu C, Luo X. Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults. Journal Of Psychiatric Research 2018, 100: 113-120. PMID: 29518578, PMCID: PMC6329582, DOI: 10.1016/j.jpsychires.2018.02.022.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug useEarly alcoholDepressive disorderOdds ratioAdult major depressive disorderMultiple logistic regression analysisConfidence intervalsMultiple logistic regressionLogistic regression analysisOverall prevalenceTobacco useUS adultsSignificant associationLogistic regressionRegression analysisNational surveyDisordersAdultsPotential factorsScoresAssociationTobaccoYearsPast year
2015
Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians
Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBeta KaryopherinsBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ARisk FactorsWhite PeopleConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeuropsychiatric disordersRare variantsHyperactivity disorderDifferent neuropsychiatric disordersRNA expression changesIndependent cohortSignificant associationSignificant regulatory effectDisordersCaucasiansEuropean descentRegulatory effectsHuman brainDiseaseAssociationCis-eQTL analysisIPO11African descentExpression changesSubjectsCohortFalse discovery rateVariants
2009
Population admixture modulates risk for alcohol dependence
Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.Peer-Reviewed Original Research