2024
Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?
Jiao Q, Dong Y, Ma X, Ji S, Liu X, Zhang J, Sun X, Li D, Luo X, Zhang Y. Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatric Disease And Treatment 2024, 20: 353-361. PMID: 38415074, PMCID: PMC10898600, DOI: 10.2147/ndt.s453447.Peer-Reviewed Original ResearchHDRS-17 total scoreFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMajor depressive disorderHDRS-17FED patientsCPT-IPCognitive functionBaseline cognitive functionTotal scoreDepressive disorderFirst-episodeDrug-naivePatients' responses to antidepressant treatmentFunctioning Assessment Short Test total scoreResponse to antidepressant treatmentHamilton Depression Rating ScaleFunctioning Assessment Short Test scoreConsensus Cognitive BatteryDepression Rating ScaleAssociated with worse cognitive functionSpeed of processingHamilton Anxiety ScaleDrug-naive patientsInterpersonal relationship domain
2022
The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia
Li H, Chen W, Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Li N, Luo X, Zhang P, Huang J, Tian L, Li CR, Tan Y. The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia. Frontiers In Psychiatry 2022, 13: 966657. PMID: 36051545, PMCID: PMC9424630, DOI: 10.3389/fpsyt.2022.966657.Peer-Reviewed Original ResearchStable chronic schizophreniaNF-κB/ILWhite matter integrityHealthy controlsMATRICS Consensus Cognitive BatteryFractional anisotropyChronic schizophreniaCortical thicknessCognitive impairmentInnate immunityCognitive functionToll-like receptor 4Higher TLR4 levelsLevels of TLR4Subcortical gray matter volumesWhite matter fractional anisotropyNegative Syndrome ScaleGray matter volumeTLR4 expressionTLR4 levelsWhite matter microstructureReceptor 4Cognitive deteriorationConsensus Cognitive BatteryLPS stimulationSerum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong L, Tan Y. Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness. Neuroscience Letters 2022, 788: 136826. PMID: 35944595, DOI: 10.1016/j.neulet.2022.136826.Peer-Reviewed Original ResearchConceptsBrain cortical thicknessCognitive impairmentCognitive deficitsGray matter thicknessSchizophrenia (MATRICS) Consensus Cognitive BatteryAttention/vigilanceConsensus Cognitive BatteryCortical thicknessSerum Hcy levelsFirst-episode patientsHealthy controlsHigh homocysteineWorking memoryHcy levelsCognitive batteryNegative Symptom ScaleCognitive functionTreatment researchHigh-resolution magnetic resonance imagingSymptom ScaleSandwich enzyme-linked immunosorbentSchizophreniaHigher cortical thicknessImpairmentEnzyme-linked immunosorbentChildhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScores
2021
Comparison of the clinical efficacy of penicillin and ceftriaxone sodium in the treatment of neurosyphilis with psychiatric symptoms.
Wang S, Gu W, Cao Y, Zheng H, Zhang L, Guo X, Chen W, Luo X. Comparison of the clinical efficacy of penicillin and ceftriaxone sodium in the treatment of neurosyphilis with psychiatric symptoms. World Journal Of Psychiatry And Mental Health Research 2021, 5 PMID: 35005746, PMCID: PMC8740858.Peer-Reviewed Original ResearchMini-Mental State ExaminationCognitive functionBrief Psychiatric Rating ScalePsychiatric symptomsTreatment of neurosyphilisMental symptomsClinical efficacySymptoms patientsPenicillin groupState ExaminationLife abilityPsychiatric Rating ScaleCeftriaxone sodiumMain time effectMMSE scoresTotal treatment timeRating ScaleSodium groupTreatment groupsNeurosyphilisSymptomsMeasurement of efficiencyPenicillinSignificant differencesPatientsEffects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2
2020
Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★
Huang J, Zhu Y, Fan F, Chen S, Hong Y, Cui Y, Luo X, Tan S, Wang Z, Shang L, Yuan Y, Zhang J, Yang F, Li CR, Rowland LM, Kochunov P, Zhang F, Hong LE, Tan Y. Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★. Psychiatry Research Neuroimaging 2020, 297: 111043. PMID: 32062167, PMCID: PMC7490244, DOI: 10.1016/j.pscychresns.2020.111043.Peer-Reviewed Original ResearchTreatment-resistant schizophreniaTreatment-responsive patientsHippocampal volumeHealthy controlsSmaller total hippocampal volumesSmaller hippocampal volumesTotal hippocampal volumeAvailable antipsychotic medicationsSevere cognitive dysfunctionLogistic regression analysisSubgroup of schizophreniaGlobal cognitive deficitsCognitive domain deficitsSpecific deficitsAntipsychotic medicationCognitive dysfunctionTreatment resistanceHigh riskHC groupPatientsMemory deficitsCognitive deficitsCognitive functionSchizophreniaSignificant deficits
2016
BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls.
Zhang XY, Chen da C, Tan YL, Tan S, Luo X, Zuo L, Soares JC. BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls. The Journal Of Clinical Psychiatry 2016, 77: e1011-8. PMID: 27561148, DOI: 10.4088/jcp.15m10269.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHealthy controlsCognitive functionBDNF gene variantsCase-control studyBDNF genetic variantsBDNF gene polymorphismPathogenesis of schizophreniaCognitive performanceRBANS total scoreHan Chinese populationBDNF polymorphismVal66Met polymorphismNeurotrophic factorBDNF geneGene polymorphismsCognitive impairmentPatientsPotential associationChinese populationNeuropsychological StatusHan Chinese individualsRepeatable BatterySchizophreniaTotal score
2013
Cognitive Function, Plasma MnSOD Activity, and MnSOD Ala-9Val Polymorphism in Patients With Schizophrenia and Normal Controls
Zhang XY, Chen D, Xiu MH, Yang FD, Tan Y, Luo X, Zuo L, Kosten TA, Kosten TR. Cognitive Function, Plasma MnSOD Activity, and MnSOD Ala-9Val Polymorphism in Patients With Schizophrenia and Normal Controls. Schizophrenia Bulletin 2013, 40: 592-601. PMID: 23588476, PMCID: PMC3984504, DOI: 10.1093/schbul/sbt045.Peer-Reviewed Original ResearchConceptsAla-9Val polymorphismNormal controlsCognitive impairmentMnSOD activityAla allele carriersChronic schizophrenic patientsMitochondrial enzyme manganese superoxide dismutaseNegative Syndrome ScaleEnzyme manganese superoxide dismutaseHealthy controlsManganese superoxide dismutaseAllele carriersExcessive reactive oxygen speciesSchizophrenic patientsSchizophrenic inpatientsSyndrome ScaleCognitive deficitsNeuropsychological StatusCognitive functionPatients' psychopathologyRepeatable BatteryPatientsSchizophreniaTotal scoreReactive oxygen species
2012
Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study
Zhang X, Chen D, Xiu M, Haile C, He S, Luo X, Zuo L, Rosenheck R, Kosten T, Kosten T. Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study. Psychological Medicine 2012, 43: 1651-1660. PMID: 23149169, DOI: 10.1017/s0033291712002590.Peer-Reviewed Original ResearchConceptsDrug-naive patientsFES patientsGeneral populationCognitive functionChronic schizophreniaHealthy controlsSmoking ratesFirst-episode drug-naive patientsFirst-episode schizophrenia patientsQuantity of smokingPositive symptom subscale scoresCase-control studyHigh smoking ratesSymptom subscale scoresCase-control designNegative Symptom ScaleTotal PANSSCigarette smokingFirst episodeNicotine dependenceFagerström TestPatientsPsychotic disordersSmokingSymptom Scale