Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking
Pei YF, Zhang L, Yang TL, Han Y, Hai R, Ran S, Tian Q, Shen H, Li J, Zhu XZ, Luo X, Deng HW. Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking. PLOS ONE 2012, 7: e30860. PMID: 22295116, PMCID: PMC3266269, DOI: 10.1371/journal.pone.0030860.Peer-Reviewed Original ResearchConceptsCopy number variantsAssociation studiesGenome-wide association studiesWide association studyGenotyping arraysAffymetrix SNP6.0Genetic mechanismsCNV regionsRelevant genesSusceptibility genesNumber variantsLTBP1GenesComplex disorderFGD4Cdc42Alcohol metabolismEnzymeSuggestive evidenceDownstreamMetabolismTGFB1ReceptorsVariantsPhysiological dependence