2023
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDiseaseMale-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain
Luo X, Lin X, Ide J, Luo X, Zhang Y, Xu J, Wang L, Chen Y, Cheng W, Zheng J, Wang Z, Yu T, Taximaimaiti R, Jing X, Wang X, Cao Y, Tan Y, Li C. Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain. Child And Adolescent Psychiatry And Mental Health 2023, 17: 4. PMID: 36609385, PMCID: PMC9824933, DOI: 10.1186/s13034-022-00536-0.Peer-Reviewed Original ResearchGray matter volumeAttention deficit hyperactivity disorderTotal intracranial volumeSubcortical gray matter volumesMRNA expressionBasal gangliaEuropean cohortABCD cohortMatter volumeCerebral gray matter volumeRisk of ADHDPathogenesis of ADHDGene-wide association studyAmygdala gray matter volumeRegulatory effectsDeficit hyperactivity disorderBrain cohortSubcortical regionsBrain regionsIntracranial volumeCohortSubcortical structuresADHD risk allelesADHD riskHyperactivity disorder
2021
An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia
Wang Z, Chen W, Cao Y, Dou Y, Fu Y, Zhang Y, Luo X, Kang L, Liu N, Shi YS, Li CR, Xu Y, Guo X, Luo X. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 385-397. PMID: 33938268, DOI: 10.1177/00048674211009595.Peer-Reviewed Original ResearchConceptsMessenger RNA expressionGray matter volumeMatter volumeSingle nucleotide polymorphismsRisk allelesRNA expressionPathogenesis of schizophreniaSingle nucleotide polymorphism (SNP) rs1006737Isthmus cingulate cortexMinor allele ARisk single nucleotide polymorphismsBrain cohortCingulate cortexBrain regionsCortical regionsSubcortical structuresSchizophreniaRs1006737Allele ARegulatory effectsRisk genesSignificant risk genesCohortCortexAfrican American sample