2023
RNA m6A methylation in psychiatric disorders.
Mao Q, Luo J, Luo X, Zhu X, Wang K, Zuo L, Zhang Y, Luo X. RNA m6A methylation in psychiatric disorders. EC Psychology And Psychiatry 2023, 12 PMID: 38145106, PMCID: PMC10745284.Peer-Reviewed Original ResearchMajor psychiatric disordersPsychiatric disordersM6A modificationM6A methyltransferase METTL3Synaptic protein synthesisInflammatory infiltrationImmune infiltrationRNA m6A methylationTherapeutic targetM6A regulatorsAlzheimer's diseaseNeuropsychiatric disordersMethyltransferase METTL3Subtype classificationPromising targetDiseaseDisordersM6A methylationInfiltrationCritical roleProtein synthesisReviewPathogenesisComprehensive reviewPreventionSpatial Multiomics Analysis in Psychiatric Disorders.
Mao Q, Huang S, Luo X, Liu P, Wang X, Wang K, Zhang Y, Chen B, Luo X. Spatial Multiomics Analysis in Psychiatric Disorders. EC Psychology And Psychiatry 2023, 12: 1-5. PMID: 37424930, PMCID: PMC10328214.Peer-Reviewed Original ResearchPsychiatric disordersAlzheimer's diseaseCommon psychiatric disordersCertain brain regionsRisk genesMiddle temporal gyrusMultiomics analysisAutism spectrum disorderAD pathologyDisease progressionOlfactory bulbSpectrum disorderMouse modelPsychiatric diseasesHuman hippocampusBrain regionsNeuropsychiatric disordersTemporal gyrusLiterature searchAid diagnosisDisordersTranscriptional signatureDiseaseHippocampusSpatial transcriptomic analysis
2022
Linear Mixed Model Analysis of Polygenic Hazard Score on Verbal Memory Decline in Alzheimer’s Disease
Wang K, Xu C, Theeke LA, Xiao D, Luo X, Xie C, Initiative A. Linear Mixed Model Analysis of Polygenic Hazard Score on Verbal Memory Decline in Alzheimer’s Disease. Nursing Research 2022, 72: 66-73. PMID: 36097266, DOI: 10.1097/nnr.0000000000000623.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TestAuditory Verbal Learning TestMini-Mental State Examination scoreVerbal Learning TestVerbal memory declineState Examination scoreAPOE ε4 alleleVerbal memory lossDisease Neuroimaging InitiativeVerbal memoryCognitive measuresLearning TestLinear mixed modelsMemory declineMild cognitive impairmentExamination scoresLongitudinal effectsLinear mixed model analysisBaseline Mini-Mental State Examination scorePolygenic hazard scoreCognitive dysfunctionCognitive impairmentMixed model analysisAlzheimer's Disease Neuroimaging InitiativeAlzheimer's disease
2020
Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI
Mu Y, Li Y, Zhang Q, Ding Z, Wang M, Luo X, Guo X, Xu M. Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI. General Psychiatry 2020, 33: e100147. PMID: 32695958, PMCID: PMC7351268, DOI: 10.1136/gpsych-2019-100147.Peer-Reviewed Original ResearchBilateral superior frontal gyrusAlzheimer's diseaseSuperior frontal gyrusMiddle frontal gyrusFrontal gyrusInferior frontal gyrusResting-state functional magnetic resonance imagingZhejiang Provincial People's HospitalBrain functional alterationsMechanisms of ADLow-frequency fluctuationsBrain activityFunctional magnetic resonance imagingMagnetic resonance imagingResting-state fMRIALFF valuesPathophysiologic featuresPeople's HospitalInclusion criteriaDepressive symptomsFunctional alterationsPatientsResonance imagingLeft inferior frontal gyrusCore symptoms
2019
Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.
Luo X, Mao Q, Shi J, Wang X, Li CR. Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders. World Journal Of Psychiatry And Mental Health Research 2019, 3 PMID: 31328186, PMCID: PMC6641567.Peer-Reviewed Original ResearchGray matter volumePutamen volumeNeurodegenerative disordersMatter volumePutamen gray matter volumesSpectrum disorderParkinson's spectrum disordersAttention deficit hyperactivity disorderSchizophrenia spectrum disordersDeficit hyperactivity disorderMultiple sclerosisLewy bodiesObsessive-compulsive spectrum disordersMajor depressionTreatment outcomesMotor impairmentDopaminergic processesNeurodegenerative conditionsAmphetamine dependenceBipolar disorderAlzheimer's diseaseCognitive deficitsHuntington's diseaseDiseaseHyperactivity disorder
2017
Bayesian Cox Proportional Hazards Model in Survival Analysis of HACE1 Gene with Age at Onset of Alzheimer's Disease
Wang KS, Liu Y, Gong S, Xu C, Xie X, Wang L, Luo X. Bayesian Cox Proportional Hazards Model in Survival Analysis of HACE1 Gene with Age at Onset of Alzheimer's Disease. International Journal Of Clinical Biostatistics And Biometrics 2017, 3 PMID: 29430571, PMCID: PMC5806706, DOI: 10.23937/2469-5831/1510014.Peer-Reviewed Original ResearchCox proportional hazards modelCox regression modelProportional hazards modelRisk of ADAAO of ADHACE1 geneAlzheimer's diseaseSurvival analysisHazards modelHazard ratioSingle nucleotide polymorphismsBayesian Cox proportional hazards modelMultiple logistic regression modelRegression modelsConfidence intervalsChronic neurodegenerative diseasesLogistic regression modelsAD patientsOnset (AAO) of ADG haplotypeNeurodegenerative disordersNeurodegenerative diseasesDiseaseStrong associationCommon formAnalysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol
Chen Y, Xu C, Harirforoosh S, Luo X, Wang KS. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal Of Psychiatric Research 2017, 96: 65-72. PMID: 28987514, PMCID: PMC6195678, DOI: 10.1016/j.jpsychires.2017.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCerebellumCholesterolComputer SimulationFamilyGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiddle AgedNeoplasmsPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2ConceptsRisk of ADRisk of cancerAlzheimer's diseaseAAO of ADSingle nucleotide polymorphismsTotal cholesterol levelsMultiple logistic regressionLDL cholesterolTotal cholesterolCholesterol levelsAD patientsCancer riskMultiple linear regression analysisLinear regression analysisNeuropsychiatric disordersLogistic regressionDiseaseCancerWilcoxon testExpression levelsRiskRegression analysisGene expression levelsHuman brainGenetic variantsFamily-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease
Wang KS, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Journal Of Neuroimmunology 2017, 310: 60-65. PMID: 28778446, PMCID: PMC6167010, DOI: 10.1016/j.jneuroim.2017.06.010.Peer-Reviewed Original ResearchConceptsRisk of ADAlzheimer's diseaseSingle nucleotide polymorphismsAAO of ADHuman brain regionsNervous system developmentApoE expressionOnset (AAO) of ADBrain regionsDiseaseSignificant expressionRiskMarker analysisGenetic variantsAssociationFamily-based association analysisHaplotype analysisPresent studyEquation statisticsAgeFirst studyOnsetFamily-based associationFamily-based sampleExpressionTranscriptome-wide piRNA profiling in human brains of Alzheimer's disease
Qiu W, Guo X, Lin X, Yang Q, Zhang W, Zhang Y, Zuo L, Zhu Y, Li CR, Ma C, Luo X. Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease. Neurobiology Of Aging 2017, 57: 170-177. PMID: 28654860, PMCID: PMC5542056, DOI: 10.1016/j.neurobiolaging.2017.05.020.Peer-Reviewed Original Research
2014
Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease
Wang KS, Tonarelli S, Luo X, Wang L, Su B, Zuo L, Mao C, Rubin L, Briones D, Xu C. Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease. Journal Of Neural Transmission 2014, 122: 701-708. PMID: 25410587, DOI: 10.1007/s00702-014-1306-z.Peer-Reviewed Original ResearchConceptsAstrotactin 2AAO of ADASTN2 geneGenome-wide association analysisSingle nucleotide polymorphism panelFuture functional studiesGenetic architectureSignificant hitsAssociation analysisGenesFunctional studiesGenetic variantsAlzheimer's diseasePathogenesis of ADGenetic profileSNPsKaplan-Meier survival analysisGenetic factorsGenotypesAD interventionAD patientsNeurological conditionsAG genotypeCognitive disordersAA genotype
2006
Variation at APOE and STH loci and Alzheimer's disease
Zuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J. Variation at APOE and STH loci and Alzheimer's disease. Behavioral And Brain Functions 2006, 2: 13. PMID: 16603077, PMCID: PMC1526745, DOI: 10.1186/1744-9081-2-13.Peer-Reviewed Original Research