Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence
Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence. American Journal Of Human Genetics 2006, 78: 973-987. PMID: 16685648, PMCID: PMC1474098, DOI: 10.1086/504113.Peer-Reviewed Original ResearchConceptsADH gene clusterGene clusterAldehyde dehydrogenase geneStructured association analysisConventional association methodsALDH2 geneAlcohol dehydrogenaseAdh geneDehydrogenase geneAssociation analysisSusceptibility lociGenesRisk genesFunctional variantsDisease allelesFunctional complexityCase-control sampleAncestry informative markersHardy-Weinberg equilibrium testDisequilibrium measuresMultiple significant associationsAllelesAlcohol-metabolizing enzymesConventional case-control comparisonsUnlinked ancestry-informative markers