2018
Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner
Li Y, Zhu T, Yang H, Dib-Hajj S, Waxman S, Yu Y, Xu TL, Cheng X. Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner. Molecular Pain 2018, 14: 1744806918782229. PMID: 29790812, PMCID: PMC6024516, DOI: 10.1177/1744806918782229.Peer-Reviewed Original ResearchConceptsND7/23 cellsDRG neuron excitabilityModulation of Nav1.7New pain therapeuticsVoltage-gated sodium channel Nav1.7Fyn kinaseWhole-cell recordingsSodium channel Nav1.7Elevated protein expressionCell type-specific modulationHuman embryonic kidney 293 cellsTyrosine kinasePain disordersEmbryonic kidney 293 cellsPain therapeuticsNeuron excitabilityPain perceptionMutant channelsChannel Nav1.7Kidney 293 cellsNav1.7HEK-293 cellsNav1.7 channelsCell type-dependent mannerType-dependent manner
2017
The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide
Yang X, Niu Y, Liu Y, Yang Y, Wang J, Cheng X, Liang H, Wang H, Hu Y, Lu X, Zhu M, Xu T, Tian Y, Yu Y. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide. Journal Of Biological Chemistry 2017, 292: 21662-21675. PMID: 29123030, PMCID: PMC5766947, DOI: 10.1074/jbc.m117.814707.Peer-Reviewed Original ResearchConceptsDEG/ENaCDegenerin/epithelial sodium channelIon channelsAcid-sensing ion channelsMammalian acid-sensing ion channelsSodium channelsDiverse functionsKey residuesEpithelial sodium channelFMRFamide peptidesAncient featureChannel gatingActivation mechanismDistinct mechanismsSubfamiliesMammalsENaCUnitary conductancePathological processesNew insightsNonproton ligandIon selectivityEndogenous agonistSynaptic transmissionFaNaCN1366S mutation of human skeletal muscle sodium channel causes paramyotonia congenita
Ke Q, Ye J, Tang S, Wang J, Luo B, Ji F, Zhang X, Yu Y, Cheng X, Li Y. N1366S mutation of human skeletal muscle sodium channel causes paramyotonia congenita. The Journal Of Physiology 2017, 595: 6837-6850. PMID: 28940424, PMCID: PMC5685822, DOI: 10.1113/jp274877.Peer-Reviewed Original ResearchIntersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors
Wang J, Sun L, Cui W, Zhao W, Ma X, Li B, Liu Y, Yang Y, Hu Y, Huang L, Cheng X, Li L, Lu X, Tian Y, Yu Y. Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors. Journal Of Biological Chemistry 2017, 292: 7619-7635. PMID: 28302727, PMCID: PMC5418059, DOI: 10.1074/jbc.m116.771121.Peer-Reviewed Original Research
2016
Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel*
Niu Y, Yang Y, Liu Y, Huang L, Yang X, Fan Y, Cheng X, Cao P, Hu Y, Li L, Lu X, Tian Y, Yu Y. Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel*. Journal Of Biological Chemistry 2016, 291: 7571-7582. PMID: 26867576, PMCID: PMC4817185, DOI: 10.1074/jbc.m115.710251.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCHO CellsCricetinaeCricetulusHEK293 CellsHumansIon Channel GatingPeptidesProtein Structure, TertiarySodium Channels