2016
Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3
Zhu X, Yuan J, Zhu T, Li Y, Cheng X. Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3. The FEBS Journal 2016, 283: 3739-3754. PMID: 27573079, DOI: 10.1111/febs.13839.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAlpha-FetoproteinsAnimalsBiomarkers, TumorCarcinoma, HepatocellularCell Line, TumorDisease ProgressionEpigenesis, GeneticGlypicansHep G2 CellsHeterograftsHistonesHumansLiver NeoplasmsMiceMice, NudePrognosisPromoter Regions, GeneticRNA, AntisenseRNA, Long NoncodingTranscriptional ActivationUp-RegulationConceptsHCC cell proliferationBarcelona Clinic Liver Cancer stageCell proliferationTranscript 1Inhibited HCC cell proliferationLiver Cancer stageHepatocellular carcinoma screeningPotential therapeutic targetXenograft tumor growthHepatocellular carcinoma progressionP300/CBP-associated factorWorse prognosisCarcinoma screeningMicrovascular invasionTumor sizeHCC patientsCancer stageTherapeutic targetHCC progressionTumor growthCarcinoma progressionPotential biomarkersPathophysiological processesHCC tissuesSignificant upregulation
2015
Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit
Lu W, Qiu L, Yan Z, Lin Z, Cao M, Hu C, Wang Z, Wang J, Yu Y, Cheng X, Cao P, Li R. Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit. Oncotarget 2015, 6: 34537-34548. PMID: 26417929, PMCID: PMC4741471, DOI: 10.18632/oncotarget.5307.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntigen PresentationBlotting, WesternCancer VaccinesCholera ToxinDisease Models, AnimalEpitopes, B-LymphocyteFemaleFluorescent Antibody TechniqueLymphocyte ActivationMiceMice, Inbred C57BLMinisatellite RepeatsMucin-1Polymerase Chain ReactionT-Lymphocytes, CytotoxicVaccines, SubunitConceptsCytotoxic T lymphocytesMUC1-specific cytotoxic T lymphocytesElicit cytotoxic T lymphocyteCytotoxic T cell responsesT cell responsesCancer vaccine designCholera toxin B subunitToxin B subunitB-cell epitopesMUC1 vaccineTumor burdenCancer vaccinesTh1 cellsT cellsT lymphocytesMouse modelCell epitopesTumor growthCell responsesTumor tissueVaccine designTumor MUC1Antigen designVaccineMUC1 peptide