Carbon Monoxide Dilates Cerebral Arterioles by Enhancing the Coupling of Ca2+ Sparks to Ca2+-Activated K+ Channels
Jaggar J, Leffler C, Cheranov S, Tcheranova D, E S, Cheng X. Carbon Monoxide Dilates Cerebral Arterioles by Enhancing the Coupling of Ca2+ Sparks to Ca2+-Activated K+ Channels. Circulation Research 2002, 91: 610-617. PMID: 12364389, DOI: 10.1161/01.res.0000036900.76780.95.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriolesCalcium Channel BlockersCalcium SignalingCarbon MonoxideCells, CulturedCerebral ArteriesCulture TechniquesElectric ConductivityHemeKineticsLysineMuscle, Smooth, VascularPotassium Channels, Calcium-ActivatedRyanodineRyanodine Receptor Calcium Release ChannelSignal TransductionSwineVasodilationVasodilator AgentsConceptsCerebral arteriolesArteriole smooth muscle cellsRelease channel blockerSmooth muscle cellsLarge-conductance Ca2Ryanodine-sensitive Ca2Enzyme heme oxygenasePial arteriolesCerebral circulationChannel blockersCoupling of Ca2Cellular signaling mechanismsPotent effectsArteriolesMuscle cellsHeme oxygenaseVasodilatorsPotent activatorControl conditionDilationPresent studySignaling mechanismCa2Source of controversyPercentage of Ca2