2011
CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells*
Bannister J, Thomas-Gatewood C, Neeb Z, Adebiyi A, Cheng X, Jaggar J. CaV1.2 Channel N-terminal Splice Variants Modulate Functional Surface Expression in Resistance Size Artery Smooth Muscle Cells*. Journal Of Biological Chemistry 2011, 286: 15058-15066. PMID: 21357696, PMCID: PMC3083159, DOI: 10.1074/jbc.m110.182816.Peer-Reviewed Original ResearchConceptsArterial smooth muscle cellsSmooth muscle cellsMuscle cellsSurface expressionIntravascular pressureSmooth muscle-specific expressionArtery smooth muscle cellsDepolarization-induced vasoconstrictionHuman cerebral arteriesWhole-cell currentsReduced surface expressionLarge vasodilationCerebral arteryInflux pathwayVariety of stimuliCardiovascular systemFunctional surface expressionVasodilationProximal N-terminusReduced expressionMuscle-specific expressionE1CAuxiliary subunitsKnockdownPhysiological functions
2009
The CaV1.2 α1 subunit N‐terminus regulates cerebral artery contractility
Bannister J, Adebiyi A, Cheng X, Zhao G, Jaggar J. The CaV1.2 α1 subunit N‐terminus regulates cerebral artery contractility. The FASEB Journal 2009, 23: 775.13-775.13. DOI: 10.1096/fasebj.23.1_supplement.775.13.Peer-Reviewed Original ResearchVoltage-dependent Ca 2Cerebral arteryMyogenic toneArterial myocytesRat cerebral arteriesCerebral artery myocytesMyogenic constrictionAcute applicationMajor Ca 2Membrane-permeant peptidePhysiological functionsSubunit expressionArteryProtein expressionE1CGreater reductionMyocytesControl peptideShRNAEntry pathwayCa 2N-terminal variantsSplice variants
2007
Myocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus
Cheng X, Liu J, Blaskova E, Asuncion‐Chin M, Bondarenko A, Dopico A, Jaggar J. Myocytes of resistance‐size arteries express CaV1.2 channels with a novel N‐terminus. The FASEB Journal 2007, 21: a1240-a1240. DOI: 10.1096/fasebj.21.6.a1240-c.Peer-Reviewed Original ResearchResistance-size arteriesIBa densityVoltage-dependent L-type Ca2Resistance-sized cerebral arteriesL-type Ca2Tissue-specific Ca2Cerebral arteryArterial myocytesSmall arteriesVascular pressuresBlood flowArteryCav1.2 geneCardiac myocytesMyocytesCav1.2 channelsCaV1.2 currentsCav1.2 subunitCysteine-rich N-terminusEntry pathwayHalf activationSpecific Ca2Principal Ca2ß-subunitHalf inactivation