Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells
Cheng X, Jaggar J. Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells. AJP Heart And Circulatory Physiology 2006, 290: h2309-h2319. PMID: 16428350, PMCID: PMC1698957, DOI: 10.1152/ajpheart.01226.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBariumCadmiumCalcium SignalingCaveolin 1ElectrophysiologyEnzyme InhibitorsFluorescent DyesFura-2IndolesMiceMice, KnockoutMicroscopy, ConfocalMicroscopy, ElectronMuscle, Smooth, VascularMyocytes, Smooth MuscleNitroargininePatch-Clamp TechniquesRyanodine Receptor Calcium Release ChannelConceptsCerebral artery smooth muscle cellsSmooth muscle cellsArtery smooth muscle cellsMuscle cellsMurine arterial smooth muscle cellsGenetic ablationNitric oxide synthase activityVoltage-dependent calcium channelsArterial smooth muscle cellsOxide synthase activitySmooth muscle contractilityChannel blockersMuscle contractilityCalcium channelsCav-1-deficient cellsSpark regulationL-typeElevated intracellularSpark frequencyPotassium channelsSarcoplasmic reticulumCurrent activationCav-1Control cellsRelease channel