Featured Publications
Classification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Classification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis. Journal Of Craniofacial Surgery 2020, 31: 678-684. PMID: 32068731, DOI: 10.1097/scs.0000000000006173.Peer-Reviewed Original ResearchConceptsClass IIICrouzon syndromeClass IClass IISuture involvementSuture synostosisSimilar craniofacial characteristicsComputed tomography scanClassification of subtypesSurgical interventionMorphology of patientsAnatomic deformityTomography scanSurgical techniqueCT scanDifferent subtypesSagittal synostosisSyndromeClass IVPremature closureCraniofacial characteristicsSevere craniofacial malformationsCranial base lengthSynostosisDifferent pathologies
2021
Aberrant Morphologic Patterning of Combined Sagittal and Metopic Craniosynostosis
Dinis J, Junn A, Lu X, Lopez J, Persing J. Aberrant Morphologic Patterning of Combined Sagittal and Metopic Craniosynostosis. Journal Of Craniofacial Surgery 2021, 32: 2184-2185. PMID: 34183627, DOI: 10.1097/scs.0000000000007676.Peer-Reviewed Original ResearchConformity of the Virtual Surgical Plan to the Actual Result Comparing Five Craniofacial Procedure Types.
Maniskas S, Pourtaheri N, Chandler L, Lu X, Bruckman KC, Steinbacher DM. Conformity of the Virtual Surgical Plan to the Actual Result Comparing Five Craniofacial Procedure Types. Plastic & Reconstructive Surgery 2021, 147: 915-924. PMID: 33776034, DOI: 10.1097/prs.0000000000007776.Peer-Reviewed Original ResearchConceptsVirtual surgical planningProcedure typeCranial vault remodelingSurgical planningOrthognathic surgeryMandibular distractionVault remodelingMandible reconstructionActual postoperative outcomesVirtual surgical planPostoperative outcomesConsecutive patientsMore predictable resultsSingle surgeonExcellent outcomesTomographic scanSkeletal repositioningPostoperative movementSurgical planBonferroni analysisIntraoperative judgmentIntraoperative guidePermanent implantsPatientsSurgeryCephalocranial Disproportionate Fossa Volume and Normal Skull Base Angle in Pfeiffer Syndrome.
Lu X, Forte AJ, Allam O, Park KE, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Cephalocranial Disproportionate Fossa Volume and Normal Skull Base Angle in Pfeiffer Syndrome. Journal Of Craniofacial Surgery 2021, 32: 581-586. PMID: 33704985, DOI: 10.1097/scs.0000000000007203.Peer-Reviewed Original ResearchConceptsPfeiffer syndrome patientsMiddle cranial fossaCranial fossaSyndrome patientsFossa volumePfeiffer patientsSurgical interventionSuture synostosisPfeiffer syndromePreoperative CT scanPosterior cranial fossa volumeAnterior cranial fossaSkull base developmentSkull base angleClinical manifestationsCraniosynostosis disordersCT scanPosterior fossaNormal controlsAnatomic basisAnterior fossaPatientsSquamosal synostosisStructural abnormalitiesSubgroup comparisonsDistinguishing craniomorphometric characteristics and severity in metopic synostosis patients
Chandler L, Park K, Allam O, Mozaffari M, Khetpal S, Smetona J, Pourtaheri N, Lu X, Persing J, Alperovich M. Distinguishing craniomorphometric characteristics and severity in metopic synostosis patients. International Journal Of Oral And Maxillofacial Surgery 2021, 50: 1040-1046. PMID: 33483210, DOI: 10.1016/j.ijom.2020.11.022.Peer-Reviewed Original Research
2020
Racial Disparity Between Asian and Caucasian Crouzon Syndrome in Skull Morphology.
Lu X, Forte AJ, Fan F, Zhang Z, Teng L, Yang B, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Racial Disparity Between Asian and Caucasian Crouzon Syndrome in Skull Morphology. Journal Of Craniofacial Surgery 2020, 31: 2182-2187. PMID: 33136851, DOI: 10.1097/scs.0000000000006741.Peer-Reviewed Original ResearchConceptsCrouzon patientsCrouzon syndromeLateral pterygoidIntracranial sideRacial disparitiesDifferent patient populationsPosterior fossa volumeCranial basePosterior cranial fossaMiddle cranial baseAsian patientsCaucasian patientsPatient populationTomographic scanPatientsCranial base angleCranial base angulationCranial fossaFossa volumeTreatment planSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
What Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis?
Lu X, Chen G, Forte AJ, Cabrejo R, Singh A, Kyle G, Steinbacher DM, Alperovich M, Alonso N, Persing JA. What Is the Skull Structure Influence of Squamosal Suture Synostosis in Nonsyndromic and Syndromic Crouzon Craniosynostosis? Journal Of Craniofacial Surgery 2019, 30: 1671-1675. PMID: 30950948, DOI: 10.1097/scs.0000000000005396.Peer-Reviewed Original ResearchConceptsMiddle cranial fossaAnterior cranial fossaCranial fossaPosterior cranial fossaSquamosal synostosisFossa volumeCrouzon syndromeSquamosal suture synostosisComputed tomography scanCranial volumeNonsyndromic craniosynostosis patientsVolume reductionSevere volume reductionTomography scanNormal controlsMorphologic effectsCraniosynostosis patientsFossaPremature closureSyndromic conditionsSuture synostosisSyndromic synostosisFrankfort horizontal planeSynostosisThree-dimensional cephalometryTemporal Evaluation of Craniofacial Relationships in Apert Syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Gabrick K, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Temporal Evaluation of Craniofacial Relationships in Apert Syndrome. Journal Of Craniofacial Surgery 2019, 30: 317-325. PMID: 30358751, DOI: 10.1097/scs.0000000000004836.Peer-Reviewed Original ResearchConceptsYears of ageApert syndromeNasal spineComputed tomography scanMaxillary planeAnterior nasal spineMonths of ageApert syndrome patientsPosterior nasal spineSella-nasion planeTomography scanSyndrome patientsAge subgroupsAnatomic relationshipsSyndromeFacial deformityAngulation changeFrankfort horizontal planeCranial base lengthMonthsIntracellular regulatory mechanismsCraniofacial malformationsAgeDeformityMaterialize software