Effects of diet-induced obesity in the development of lymphedema in the animal model: A literature review
Khan N, Huayllani MT, Lu X, Boczar D, Cinotto G, Avila FR, Guliyeva G, Forte AJ. Effects of diet-induced obesity in the development of lymphedema in the animal model: A literature review. Obesity Research & Clinical Practice 2022, 16: 197-205. PMID: 35659463, DOI: 10.1016/j.orcp.2022.05.003.Peer-Reviewed Original ResearchConceptsAerobic exerciseT cellsAnimal modelsLymphatic dysfunctionEffect of obesityLipid metabolism disordersDiet-induced obesityHigh-fat dietDevelopment of lymphedemaAdipose tissue depositionVEGFR-3 expressionImpaired lymphatic drainageInhibition of lymphangiogenesisUnderlying cellular mechanismsInflammatory cascadeOvid EmbaseDiet/Metabolism disordersPharmacological interventionsEligibility criteriaLymphatic drainageContractile propertiesLong-term exposureObesityLymphatic endothelial cells