2014
PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia
Xiao J, Lee S, Xiao Y, Ma X, Houseman EA, Hsu L, Roy R, Wrensch M, de Smith A, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. International Journal Of Cancer 2014, 135: 1101-1109. PMID: 24496747, PMCID: PMC4776754, DOI: 10.1002/ijc.28759.Peer-Reviewed Original ResearchMeSH KeywordsCell Transformation, NeoplasticChildChild, PreschoolDNA MethylationDNA-Binding ProteinsEnzyme ActivationEpigenesis, GeneticExtracellular Signal-Regulated MAP KinasesGene Expression Regulation, LeukemicHEK293 CellsHumansMutationPhosphorylationPrecursor Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, GeneticRas ProteinsReceptor-Like Protein Tyrosine Phosphatases, Class 5Transcription FactorsTranscriptional ActivationConceptsDNA methylationPTPRG expressionDNA methylation profilesDNA methylation statusDephosphorylation of ERKMember genesEpigenetic mechanismsGene activationMutant RASRAS gene activationMethylation profilesGene expressionPtprg geneMethylation statusCell growthAdditional roleMethylationPotential therapeutic targetCell linesGenetic characteristicsGenesLeukemia phenotypeTherapeutic targetMutationsExpression
2008
Infection and pediatric acute lymphoblastic leukemia
Ma X, Urayama K, Chang J, Wiemels JL, Buffler PA. Infection and pediatric acute lymphoblastic leukemia. Blood Cells Molecules And Diseases 2008, 42: 117-120. PMID: 19064328, PMCID: PMC2834409, DOI: 10.1016/j.bcmd.2008.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetCase-Control StudiesChildChild Day Care CentersChild, PreschoolClone CellsCocarcinogenesisEmploymentForecastingHumansInfantInfectionsModels, BiologicalMutationNorth CarolinaParentsPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesRisk FactorsVaccinationConceptsNorthern California Childhood Leukemia StudyVaccination historyPediatric acute lymphoblastic leukemiaAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChild's vaccination historyChildhood Leukemia StudyDaycare attendanceLymphoblastic leukemiaInfectious agentsImmune systemLeukemia StudyChildren's exposureInfectionRecent findingsExposureSocial contactLeukemia
2005
RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 2005, 19: 415-419. PMID: 15674422, DOI: 10.1038/sj.leu.2403641.Peer-Reviewed Original ResearchConceptsRAS mutationsMaternal ageLeukemia casesPediatric acute lymphoblastic leukemiaAcute lymphoblastic leukemia casesDiagnostic bone marrow samplesIncident leukemia casesPaternal preconception smokingNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaLymphoblastic leukemia casesBone marrow samplesKRAS codon 12California Childhood Leukemia StudyRAS gene mutationsChildhood Leukemia StudyEtiology of subtypesPreconception smokingCase seriesLymphoblastic leukemiaLeukemia patientsMultivariable modelMarrow samplesHigh hyperdiploidyChildhood leukemia