Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations.
Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 697-700. PMID: 11401921.Peer-Reviewed Original ResearchConceptsPediatric populationBuccal cellsNurse-administered protocolGlutathione S-transferase muPediatric acute leukemiaMethylenetetrahydrofolate reductase (MTHFR) polymorphismsPeripheral whole bloodGlutathione S-transferase thetaAcute leukemiaCytology brushWhole genome amplificationChildhood leukemiaBone marrowBuccal cell DNANoninvasive methodWhole bloodRepeat testsSuccess rateGenome amplificationOngoing studiesBuccal samplesLeukemiaBloodBuccal DNACell DNA