2016
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood 2016, 129: 1680-1684. PMID: 27979823, PMCID: PMC5364339, DOI: 10.1182/blood-2016-07-723148.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCMV infectionCytomegalovirus infectionLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaUtero cytomegalovirus infectionCongenital CMV infectionCommon childhood cancerActive viral transcriptionBone marrow specimensNon-Hispanic whitesTiming of infectionNewborn blood samplesEtiologic roleRisk factorsChildhood cancerHealthy controlsHigh prevalenceMarrow specimensLeukemia blastsBlood samplesPrenatal originEtiologic agentInfectionHispanic childrenAir toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study
Symanski E, Tee Lewis PG, Chen TY, Chan W, Lai D, Ma X. Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. Environmental Health 2016, 15: 70. PMID: 27301866, PMCID: PMC4908700, DOI: 10.1186/s12940-016-0154-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsBenzeneButadienesCase-Control StudiesChild, PreschoolEnvironmental MonitoringFemaleHumansInfantInfant, NewbornMaleMaternal ExposureOdds RatioPolycyclic Aromatic HydrocarbonsPrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPrenatal Exposure Delayed EffectsTexasYoung AdultConceptsAcute lymphocytic leukemiaCo-pollutant modelsCase-control studySingle-pollutant modelsChildhood leukemiaLymphocytic leukemiaChildhood acute lymphocytic leukemiaBirth certificatesCancer registry casesPopulation-based controlsEarly life exposureMixed effects logistic regression modelsEarly childhood risksLogistic regression modelsPotential confoundersEtiologic roleLowest quartileRegistry casesInfant characteristicsLife exposurePediatric cancerMaternal addressControl studyBirth recordsLeukemia
2005
Ethnic Difference in Daycare Attendance, Early Infections, and Risk of Childhood Acute Lymphoblastic Leukemia
Ma X, Buffler PA, Wiemels JL, Selvin S, Metayer C, Loh M, Does MB, Wiencke JK. Ethnic Difference in Daycare Attendance, Early Infections, and Risk of Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 1928-1934. PMID: 16103439, DOI: 10.1158/1055-9965.epi-05-0115.Peer-Reviewed Original ResearchConceptsNon-Hispanic white childrenAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaDaycare attendanceLymphoblastic leukemiaC-ALLOdds ratioEarly infectionWhite childrenNorthern California Childhood Leukemia StudyPossible etiologic roleRisk of childhoodEthnic differencesCalifornia Childhood Leukemia StudyChildhood Leukemia StudyDose-response relationshipImportant ethnic differencesEar infectionsEtiologic roleInfectious agentsMagnitude of effectInfectionDisease hypothesisLeukemia StudyHispanic children
2002
Critical windows of exposure to household pesticides and risk of childhood leukemia.
Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental Health Perspectives 2002, 110: 955-960. PMID: 12204832, PMCID: PMC1240997, DOI: 10.1289/ehp.02110955.Peer-Reviewed Original ResearchConceptsHigh riskChildhood leukemiaNorthern California Childhood Leukemia StudyPotential etiologic roleCalifornia Childhood Leukemia StudyHousehold pesticidesLocation of exposureChildhood Leukemia StudyHousehold pesticide exposureBirth RegistryControl subjectsEtiologic roleElevated riskSignificant associationLeukemiaPregnancyCritical windowLeukemia StudyLate exposureFrequent exposurePesticide exposureRiskExposureYear 2Year 1