2022
Accelerated epigenetic aging in newborns with Down syndrome
Xu K, Li S, Muskens IS, Elliott N, Myint SS, Pandey P, Hansen HM, Morimoto LM, Kang AY, Ma X, Metayer C, Mueller BA, Roberts I, Walsh KM, Horvath S, Wiemels JL, de Smith A. Accelerated epigenetic aging in newborns with Down syndrome. Aging Cell 2022, 21: e13652. PMID: 35661546, PMCID: PMC9282838, DOI: 10.1111/acel.13652.Peer-Reviewed Original ResearchConceptsDown syndromeAge accelerationEpigenetic age accelerationGestational age accelerationEarly-onset Alzheimer's diseaseTransient abnormal myelopoiesisPotential confounding factorsEpigenetic agingPremature agingSomatic GATA1 mutationsDS patientsAbnormal myelopoiesisBlood cell proportionsNewbornsAlzheimer's diseaseConfounding factorsBrain tissueCell proportionGATA1 mutationsEndocrine systemBloodTargeted sequencingSomatic mutationsSyndromeDisease
2001
Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations.
Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 697-700. PMID: 11401921.Peer-Reviewed Original ResearchConceptsPediatric populationBuccal cellsNurse-administered protocolGlutathione S-transferase muPediatric acute leukemiaMethylenetetrahydrofolate reductase (MTHFR) polymorphismsPeripheral whole bloodGlutathione S-transferase thetaAcute leukemiaCytology brushWhole genome amplificationChildhood leukemiaBone marrowBuccal cell DNANoninvasive methodWhole bloodRepeat testsSuccess rateGenome amplificationOngoing studiesBuccal samplesLeukemiaBloodBuccal DNACell DNA