2018
Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine
Fukumoto K, Fogaça M, Liu RJ, Duman C, Kato T, Li XY, Duman RS. Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 116: 297-302. PMID: 30559184, PMCID: PMC6320534, DOI: 10.1073/pnas.1814709116.Peer-Reviewed Original ResearchConceptsActivity-dependent BDNF releaseAntidepressant effectsAntidepressant actionBDNF releaseActivity-dependent brain-derived neurotrophic factorL-type voltage-dependent CaSynaptic functionBrain-derived neurotrophic factorMajor depressive disorder patientsMethyl-d-aspartate (NMDA) receptor antagonistIntra-mPFC microinjectionRapid antidepressant effectsDepressive disorder patientsTreatment of MDDBDNF Val66Met allelesVoltage-dependent CaIntra-mPFC infusionMetabolite of ketamineDownstream TrkBNeurotrophic factorReceptor antagonistNMDA receptorsMolecular signaling mechanismsRodent modelsDisorder patients
2015
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biological Psychiatry 2015, 80: 12-22. PMID: 26831917, DOI: 10.1016/j.biopsych.2015.11.026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnhedoniaAnimalsAnxietyBehavior, AnimalDepressionDisease Models, AnimalInflammasomesInterleukin-1betaMaleMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P2Y2Stress, PsychologicalTumor Necrosis Factor-alphaConceptsTumor necrosis factor alphaAcute restraint stressNecrosis factor alphaIL-1βRestraint stressFactor alphaExtracellular adenosine triphosphateAntagonist administrationDepressive behaviorNLRP3 inflammasomeChronic unpredictable stress exposureInflammatory cytokines IL-1βStress-related mood disordersStress-induced cytokineChronic unpredictable stressStress-induced inflammationCytokines IL-1βAdenosine triphosphateMajor depressive disorderNovel therapeutic targetInnate immune systemWestern blot analysisComorbid illnessesP2X7R antagonistsInflammasome cascade
2007
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
Banasr M, Valentine GW, Li XY, Gourley SL, Taylor JR, Duman RS. Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat. Biological Psychiatry 2007, 62: 496-504. PMID: 17585885, DOI: 10.1016/j.biopsych.2007.02.006.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressCell proliferationAdult ratsPrefrontal cortexChronic antidepressant administrationNumber of gliaNumber of oligodendrocytesPotential cellular mechanismsCortical cell proliferationDecrease cell proliferationAntidepressant administrationCUS paradigmGlial reductionCerebral cortexSucrose preferenceDepressed patientsMorphologic findingsPostmortem studiesUnpredictable stressDepressed subjectsBrain tissueChronic stressEndothelial cellsCellular actionsCortex