2009
Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus
Su XW, Li XY, Banasr M, Koo JW, Shahid M, Henry B, Duman RS. Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus. Psychopharmacology 2009, 206: 215-222. PMID: 19603152, DOI: 10.1007/s00213-009-1598-0.Peer-Reviewed Original ResearchConceptsOrg 26576Neuronal cell proliferationHippocampal neurogenesisChronic administrationAntidepressant propertiesCell proliferationDentate gyrusPrelimbic cortexMethodsMale Sprague–Dawley ratsAdult rodent hippocampusLast drug injectionDaily intraperitoneal injectionsSprague-Dawley ratsIsoxazolepropionic acid receptor potentiatorsDifferentiation of neuronsRate of survivalResultsAcute administrationAvailable antidepressantsProgenitor cell proliferationChronic treatmentCurrent antidepressantsIntraperitoneal injectionDrug injectionAdult ratsReceptor potentiators
2007
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
Banasr M, Valentine GW, Li XY, Gourley SL, Taylor JR, Duman RS. Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat. Biological Psychiatry 2007, 62: 496-504. PMID: 17585885, DOI: 10.1016/j.biopsych.2007.02.006.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressCell proliferationAdult ratsPrefrontal cortexChronic antidepressant administrationNumber of gliaNumber of oligodendrocytesPotential cellular mechanismsCortical cell proliferationDecrease cell proliferationAntidepressant administrationCUS paradigmGlial reductionCerebral cortexSucrose preferenceDepressed patientsMorphologic findingsPostmortem studiesUnpredictable stressDepressed subjectsBrain tissueChronic stressEndothelial cellsCellular actionsCortex