2020
Neuron-specific deletion of VEGF or its receptor Flk-1 impairs recognition memory
Deyama S, Li XY, Duman RS. Neuron-specific deletion of VEGF or its receptor Flk-1 impairs recognition memory. European Neuropsychopharmacology 2020, 31: 145-151. PMID: 31902568, DOI: 10.1016/j.euroneuro.2019.11.002.Peer-Reviewed Original ResearchConceptsNeuron-specific deletionCognitive impairmentFlk-1Chemotherapy-induced cognitive impairmentNovel object recognition testVascular endothelial growth factorObject recognition testConditional knockout miceEndothelial growth factorFetal liver kinase-1Liver kinase-1Impairs recognition memoryPerivascular macrophagesRecognition memoryVEGF inhibitorsPreclinical studiesKnockout miceEndothelial cellsMiceGrowth factorPleiotropic factorLong-term recognition memoryVEGFImpairmentVEGF Signaling
2015
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biological Psychiatry 2015, 80: 12-22. PMID: 26831917, DOI: 10.1016/j.biopsych.2015.11.026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnhedoniaAnimalsAnxietyBehavior, AnimalDepressionDisease Models, AnimalInflammasomesInterleukin-1betaMaleMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P2Y2Stress, PsychologicalTumor Necrosis Factor-alphaConceptsTumor necrosis factor alphaAcute restraint stressNecrosis factor alphaIL-1βRestraint stressFactor alphaExtracellular adenosine triphosphateAntagonist administrationDepressive behaviorNLRP3 inflammasomeChronic unpredictable stress exposureInflammatory cytokines IL-1βStress-related mood disordersStress-induced cytokineChronic unpredictable stressStress-induced inflammationCytokines IL-1βAdenosine triphosphateMajor depressive disorderNovel therapeutic targetInnate immune systemWestern blot analysisComorbid illnessesP2X7R antagonistsInflammasome cascade