2015
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS. Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biological Psychiatry 2015, 80: 12-22. PMID: 26831917, DOI: 10.1016/j.biopsych.2015.11.026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnhedoniaAnimalsAnxietyBehavior, AnimalDepressionDisease Models, AnimalInflammasomesInterleukin-1betaMaleMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPurinergic P2Y Receptor AgonistsPurinergic P2Y Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P2Y2Stress, PsychologicalTumor Necrosis Factor-alphaConceptsTumor necrosis factor alphaAcute restraint stressNecrosis factor alphaIL-1βRestraint stressFactor alphaExtracellular adenosine triphosphateAntagonist administrationDepressive behaviorNLRP3 inflammasomeChronic unpredictable stress exposureInflammatory cytokines IL-1βStress-related mood disordersStress-induced cytokineChronic unpredictable stressStress-induced inflammationCytokines IL-1βAdenosine triphosphateMajor depressive disorderNovel therapeutic targetInnate immune systemWestern blot analysisComorbid illnessesP2X7R antagonistsInflammasome cascade
2011
Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, Li XY, Aghajanian G, Duman RS. Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure. Biological Psychiatry 2011, 69: 754-761. PMID: 21292242, PMCID: PMC3068225, DOI: 10.1016/j.biopsych.2010.12.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBlotting, WesternChoice BehaviorDendritic SpinesElectrophysiologyExcitatory Amino Acid AntagonistsKetamineNeuronsPhenolsPiperidinesPrefrontal CortexRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSignal TransductionSirolimusStress, PhysiologicalStress, PsychologicalSynapsesSynaptic TransmissionConceptsGlutamate N-methyl-d-aspartate (NMDA) receptor antagonistN-methyl-D-aspartate receptor antagonistNMDA receptor antagonistReceptor antagonistLayer V pyramidal neuronsChronic unpredictable stress modelMammalian targetStress exposureDepressant-like behaviorLong-term stress exposurePathophysiology of depressionRapid antidepressant actionsSelective NMDA receptorChronic stress exposurePrefrontal cortex neuronsAntidepressant actionAcute treatmentChronic administrationSynaptic deficitsPyramidal neuronsSpine densityRo 25Cortex neuronsFunctional deficitsNMDA receptors
2007
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
Banasr M, Valentine GW, Li XY, Gourley SL, Taylor JR, Duman RS. Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat. Biological Psychiatry 2007, 62: 496-504. PMID: 17585885, DOI: 10.1016/j.biopsych.2007.02.006.Peer-Reviewed Original ResearchConceptsChronic unpredictable stressCell proliferationAdult ratsPrefrontal cortexChronic antidepressant administrationNumber of gliaNumber of oligodendrocytesPotential cellular mechanismsCortical cell proliferationDecrease cell proliferationAntidepressant administrationCUS paradigmGlial reductionCerebral cortexSucrose preferenceDepressed patientsMorphologic findingsPostmortem studiesUnpredictable stressDepressed subjectsBrain tissueChronic stressEndothelial cellsCellular actionsCortex