2020
Neuron-specific deletion of VEGF or its receptor Flk-1 impairs recognition memory
Deyama S, Li XY, Duman RS. Neuron-specific deletion of VEGF or its receptor Flk-1 impairs recognition memory. European Neuropsychopharmacology 2020, 31: 145-151. PMID: 31902568, DOI: 10.1016/j.euroneuro.2019.11.002.Peer-Reviewed Original ResearchConceptsNeuron-specific deletionCognitive impairmentFlk-1Chemotherapy-induced cognitive impairmentNovel object recognition testVascular endothelial growth factorObject recognition testConditional knockout miceEndothelial growth factorFetal liver kinase-1Liver kinase-1Impairs recognition memoryPerivascular macrophagesRecognition memoryVEGF inhibitorsPreclinical studiesKnockout miceEndothelial cellsMiceGrowth factorPleiotropic factorLong-term recognition memoryVEGFImpairmentVEGF Signaling
2009
Eszopiclone and fluoxetine enhance the survival of newborn neurons in the adult rat hippocampus
Su XW, Li XY, Banasr M, Duman RS. Eszopiclone and fluoxetine enhance the survival of newborn neurons in the adult rat hippocampus. The International Journal Of Neuropsychopharmacology 2009, 12: 1421-1428. PMID: 19775501, PMCID: PMC3677220, DOI: 10.1017/s1461145709990629.Peer-Reviewed Original ResearchConceptsNewborn neuronsAntidepressant actionSerotonin uptake inhibitorAdult rat hippocampusAdult hippocampusCombined administrationDorsal hippocampusRat hippocampusPreclinical studiesAdult ratsUptake inhibitorFluoxetineHippocampusNewborn cellsClinical researchEszopicloneBehavioral actionsNeuronsSurvivalAdditive effectNovel mechanismProliferationAntidepressantsPatientsChronic