The neurotrophic and antidepressant actions of BDNF and VEGF require interactive signaling
Deyama S, Baing E, Kato T, Li X, Duman R. The neurotrophic and antidepressant actions of BDNF and VEGF require interactive signaling. Proceedings For Annual Meeting Of The Japanese Pharmacological Society 2018, WCP2018: po2-1-62. DOI: 10.1254/jpssuppl.wcp2018.0_po2-1-62.Peer-Reviewed Original ResearchBrain-derived neurotrophic factorVascular endothelial growth factorMedial prefrontal cortexAntidepressant actionAntidepressant effectsDendritic complexityNeurotrophic factorCortical neuronsPrimary cultured cortical neuronsNovelty-suppressed feeding testNeuronal vascular endothelial growth factorGrowth factorNeuron-specific deletionCultured cortical neuronsActivity-dependent releasePrimary cortical neuronsEndothelial growth factorIntra-mPFC infusionBDNF-TrkBBDNF receptorAntidepressant responseBDNF infusionSwim testVEGF infusionNeurotrophic responses