2016
Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer
Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 2016, 14: 563-573. PMID: 26983689, PMCID: PMC4912439, DOI: 10.1158/1541-7786.mcr-15-0450.Peer-Reviewed Original ResearchConceptsContext-specific functionsKinase-independent mannerEpithelial-mesenchymal transitionOncogenic signalingEpithelial phenotypeXenograft tumor growthCell survivalExpression of PTK6Protein tyrosine kinase 6DNA-damaging treatmentsTumor suppressor functionTyrosine kinase 6Colon cancer cellsDifferentiated epithelial cellsPTK6 knockdownTumor tissue arraysColon tumor cell linesHuman colon tumor cell linesPTK6 expressionKinase 6ERK5 activationPTK6Tumor growthDNA damageSuppressor function
2010
Colorectal Cancer Susceptibility Quantitative Trait Loci in Mice as a Novel Approach to Detect Low-Penetrance Variants in Humans: A Two-Stage Case-Control Study
Fernández-Rozadilla C, Tarrío R, Clofent J, de Castro L, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C, Association F. Colorectal Cancer Susceptibility Quantitative Trait Loci in Mice as a Novel Approach to Detect Low-Penetrance Variants in Humans: A Two-Stage Case-Control Study. Cancer Epidemiology Biomarkers & Prevention 2010, 19: 619-623. PMID: 20142256, DOI: 10.1158/1055-9965.epi-09-1175.Peer-Reviewed Original ResearchConceptsQuantitative trait lociLow-penetrance variantsTrait lociSingle nucleotide polymorphismsSusceptibility quantitative trait lociMouse quantitative trait lociHuman candidate genesSyntenic regionsGene selection strategyGenetic basisCyr61 geneCandidate genesPenetrant mutationsGenesLociPolygenic modelCancer susceptibilityEarly CRC detectionColorectal cancer susceptibilityGenetic modelingCRC riskPolymorphismColorectal cancerVariantsCRC detection
1999
BRK/Sik expression in the gastrointestinal tract and in colon tumors.
Llor X, Serfas MS, Bie W, Vasioukhin V, Polonskaia M, Derry J, Abbott CM, Tyner AL. BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clinical Cancer Research 1999, 5: 1767-77. PMID: 10430081.Peer-Reviewed Original ResearchConceptsNormal gastrointestinal tractGastrointestinal tractBrk expressionColon tumorsPrimary colon tumorsCell linesAdenocarcinoma cell lineNormal epithelial cellsBRK tyrosine kinaseColon adenocarcinoma cell lineEpithelial tumorsImmunohistochemical assaysColon tumor cell linesTumor cell linesTumor samplesTractTumorsEpithelial cellsColon tumor samplesIntestinal cDNA libraryRNase protection