2021
Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant
MacFarland SP, Ebrahimzadeh JE, Zelley K, Begum L, Bass LM, Brand RE, Dudley B, Fishman DS, Ganzak A, Karloski E, Latham A, Llor X, Plon S, Riordan MK, Scollon SR, Stadler ZK, Syngal S, Ukaegbu C, Weiss JM, Yurgelun MB, Brodeur GM, Mamula P, Katona BW. Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant. Cancer Prevention Research 2021, 14: 215-222. PMID: 33097490, PMCID: PMC8557953, DOI: 10.1158/1940-6207.capr-20-0348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBone Morphogenetic Protein Receptors, Type IChildChild, PreschoolColectomyColonoscopyFemaleFollow-Up StudiesGerm-Line MutationHumansIntestinal PolyposisMaleMedical History TakingMiddle AgedNeoplastic Syndromes, HereditaryPractice Guidelines as TopicPrecision MedicineSmad4 ProteinWatchful WaitingYoung AdultConceptsJuvenile polyposis syndromePolyposis syndromeFamily historyDisease-causing variantsCancer riskGermline disease-causing variantsGastrointestinal cancer predisposition syndromesUpper gastrointestinal polypsHamartomatous polyposis syndromesCancer predisposition syndromeLifelong surveillanceAdult centersDuodenal polypsGastrointestinal cancerCancer historySubgroup analysisIndividualized managementLower riskGastrointestinal polypsPredisposition syndromeSyndromeYounger ageDistinct phenotypic differencesLower likelihoodGastrectomy
2020
AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States
Melson JE, Imperiale TF, Itzkowitz SH, Llor X, Kochman ML, Grady WM, Schoen RE, Burke CA, Shaukat A, Rabeneck L, Ladabaum U, Bresalier R, Spiegel B, Yee J, Wang T, Lieberman D, Komanduri S, Muthusamy VR, Dey N. AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States. Clinical Gastroenterology And Hepatology 2020, 18: 2667-2678.e2. PMID: 32634626, DOI: 10.1016/j.cgh.2020.06.053.Peer-Reviewed Original ResearchMeSH KeywordsColonoscopyColorectal NeoplasmsEarly Detection of CancerHumansMass ScreeningRisk AssessmentUnited StatesConceptsColorectal cancer screeningCancer screeningBetter risk-stratify patientsMultiple screening modalitiesRisk-stratify patientsNoninvasive screening testAmerican Gastroenterological Association's CenterPersonal risk assessmentCRC morbidityCRC screeningCRC outcomesScreening modalityConsensus conferenceScreening testAssociation centerOutcomesScreeningTesting paradigmSurveillanceMorbidityPatientsRisk assessmentMortalityUptake
2010
Extent of prevalence and size of flat neoplasms in a heterogeneous population undergoing routine colorectal cancer screening
Kim J, Rami P, O’Toole J, Llor X, Carroll RE, Benya RV. Extent of prevalence and size of flat neoplasms in a heterogeneous population undergoing routine colorectal cancer screening. Colorectal Disease 2010, 12: 471-476. PMID: 19298579, DOI: 10.1111/j.1463-1318.2009.01822.x.Peer-Reviewed Original ResearchConceptsExtent of prevalenceFlat neoplasmsAdvanced pathologyRoutine colorectal cancer screeningColorectal cancer screeningFlat colorectal neoplasmsColorectal cancerMean agePatient populationScreening clinicCancer screeningColorectal neoplasmsRoutine screeningGeneral populationNeoplasmsPrevalencePatientsAfrican AmericansPathologyHeterogeneous populationDiverse populationsPopulationScreeningClinicLesions
2008
Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology
Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV. Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 1155-1162. PMID: 18483337, DOI: 10.1158/1055-9965.epi-07-2731.Peer-Reviewed Original ResearchConceptsAberrant crypt fociSmall aberrant crypt fociHyperplastic polypsDistal adenomasColorectal cancerOdds ratioLarge aberrant crypt fociRoutine colorectal cancerCancer chemoprevention studiesDistal hyperplastic polypsAfrican AmericansACF prevalenceACF sizePatient ageACF numberChemoprevention studiesCrypt fociSurrogate markerHistopathologic lesionsUnselected populationPatientsTissue planesAdenomasPolypsHistopathology
2007
Detection of Metachronous Neoplasms in Colorectal Cancer Patients: Identification of Risk Factors
Ballesté B, Bessa X, Piñol V, CastellvíBel S, Castells A, Alenda C, Paya A, Jover R, Xicola RM, Pons E, Llor X, Cordero C, FernandezBañares F, de Castro L, Reñé JM, Andreu M. Detection of Metachronous Neoplasms in Colorectal Cancer Patients: Identification of Risk Factors. Diseases Of The Colon & Rectum 2007, 50: 971-980. PMID: 17468913, DOI: 10.1007/s10350-007-0237-2.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAgedColonoscopyColorectal NeoplasmsConfidence IntervalsDNA RepairDNA, NeoplasmFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHumansImmunohistochemistryIncidenceMaleMicrosatellite InstabilityMutL Protein Homolog 1MutS Homolog 2 ProteinNeoplasms, Second PrimaryNuclear ProteinsOdds RatioPrognosisProspective StudiesSpainTime FactorsConceptsMetachronous colorectal neoplasmsMetachronous neoplasmsColorectal cancerSynchronous adenomasPredictive factorsColorectal neoplasmsGeneral population-based studyPrevious colorectal cancerIndependent predictive factorsColorectal cancer patientsInflammatory bowel diseasePresence of adenomasSubgroup of patientsPopulation-based studySynchronous colorectal adenomasSpecific surveillance strategiesFamilial adenomatous polyposisDNA microsatellite instabilityBowel diseaseCancer patientsRisk factorsColorectal adenomasSpanish hospitalsFamily historyHigh riskLow adherence to colonoscopy in the screening of first-degree relatives of patients with colorectal cancer
Bujanda L, Sarasqueta C, Zubiaurre L, Cosme A, Muñoz C, Sánchez A, Martín C, Tito L, Piñol V, Castells A, Llor X, Xicola RM, Pons E, Clofent J, de Castro ML, Cuquerella J, Medina E, Gutierrez A, Arenas JI, Jover R. Low adherence to colonoscopy in the screening of first-degree relatives of patients with colorectal cancer. Gut 2007, 56: 1714. PMID: 17400596, PMCID: PMC2095719, DOI: 10.1136/gut.2007.120709.Peer-Reviewed Original ResearchConceptsFirst-degree relativesColorectal cancerIndex patientsStudy populationRate of adherenceRelatives of patientsFamilial aggregationAdherence ratesFemale sexAdvanced lesionsLow adherenceNationwide studyPatientsCancerEPICOLON studyLesionsAdherenceFemale relativesMethod of choiceSiblingsPopulationYearsMulticentreRelativesColonoscopy