2013
Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling
Montero-Meléndez T, Llor X, García-Planella E, Perretti M, Suárez A. Identification of Novel Predictor Classifiers for Inflammatory Bowel Disease by Gene Expression Profiling. PLOS ONE 2013, 8: e76235. PMID: 24155895, PMCID: PMC3796518, DOI: 10.1371/journal.pone.0076235.Peer-Reviewed Original ResearchMeSH KeywordsColitis, UlcerativeCrohn DiseaseGene Expression ProfilingGene Expression RegulationHumansInflammationInflammatory Bowel DiseasesOligonucleotide Array Sequence AnalysisPhenotypeReal-Time Polymerase Chain ReactionReproducibility of ResultsConceptsInflammatory bowel diseaseIBD patientsBowel diseaseGene expression profilingGlucocorticoid receptor degradationDegree of inflammationIntestinal inflammationPatients' qualityPinch biopsiesDifferential diagnosisImmune responseEffective treatmentSide effectsClinical practiceExpression profilingNew biomarkersMicroarray gene expression profilingPersonalized approachPatientsPersonalized therapyCurrent markersTranscriptional signatureInter-individual differencesGene expression profilesInflammation
2011
Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype
Sohn VR, Giros A, Xicola RM, Fluvià L, Grzybowski M, Anguera A, Llor X. Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. British Journal Of Nutrition 2011, 107: 1591-1602. PMID: 22018732, DOI: 10.1017/s0007114511004910.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, PhytogenicApoptosisBacteria, AnaerobicBcl-2 Homologous Antagonist-Killer ProteinBcl-X ProteinCell Line, TumorColorectal NeoplasmsFatty Acids, VolatileFecesFermentationGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMembrane Potential, MitochondrialNeoplasm ProteinsOligonucleotide Array Sequence AnalysisPlant EpidermisPlantagoRNA, MessengerSeedsConceptsMolecular phenotypesExtrinsic pathwayDeath receptor-mediated apoptosisDeath domain proteinActivator of caspaseMitochondrial membrane depolarisationApoptosis-inducing factorReceptor-mediated apoptosisInhibitor of apoptosisLoVo cellsRegulation of inhibitorAdenomatous polyposis coliTNF-α ligandDomain proteinsMetastatic cell linesPro-apoptotic environmentCaspase activatorsCRC cellsApoptotic proteaseDifferent molecular phenotypesPro-apoptotic effectsDeath receptorsPlantago ovata huskApoptosis survivinIntrinsic pathway