2016
Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer
Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 2016, 14: 563-573. PMID: 26983689, PMCID: PMC4912439, DOI: 10.1158/1541-7786.mcr-15-0450.Peer-Reviewed Original ResearchConceptsContext-specific functionsKinase-independent mannerEpithelial-mesenchymal transitionOncogenic signalingEpithelial phenotypeXenograft tumor growthCell survivalExpression of PTK6Protein tyrosine kinase 6DNA-damaging treatmentsTumor suppressor functionTyrosine kinase 6Colon cancer cellsDifferentiated epithelial cellsPTK6 knockdownTumor tissue arraysColon tumor cell linesHuman colon tumor cell linesPTK6 expressionKinase 6ERK5 activationPTK6Tumor growthDNA damageSuppressor function
2010
Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort
Fernández-Rozadilla C, de Castro L, Clofent J, Brea-Fernández A, Bessa X, Abulí A, Andreu M, Jover R, Xicola R, Llor X, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C, . Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort. PLOS ONE 2010, 5: e12673. PMID: 20844743, PMCID: PMC2936577, DOI: 10.1371/journal.pone.0012673.Peer-Reviewed Original ResearchConceptsBMP pathwayLow-penetrance variantsNew susceptibility lociNew risk variantsCandidate gene studiesCarcinogenesis-related pathwaysPathway-based studiesRegulatory SNPsSingle nucleotide polymorphismsAssociation studiesCase-control association studySusceptibility lociGenesSusceptibility variantsRisk variantsNucleotide polymorphismsComplex diseasesSigns of associationPolygenic modelPathwayWntHaplotypic analysisGenetic susceptibilityNatural strategyVariants
2009
Regulation of Colorectal Cancer Cell Apoptosis by the n-3 Polyunsaturated Fatty Acids Docosahexaenoic and Eicosapentaenoic
Giros A, Grzybowski M, Sohn VR, Pons E, Fernandez-Morales J, Xicola RM, Sethi P, Grzybowski J, Goel A, Boland CR, Gassull MA, Llor X. Regulation of Colorectal Cancer Cell Apoptosis by the n-3 Polyunsaturated Fatty Acids Docosahexaenoic and Eicosapentaenoic. Cancer Prevention Research 2009, 2: 732-742. PMID: 19638488, PMCID: PMC3793343, DOI: 10.1158/1940-6207.capr-08-0197.Peer-Reviewed Original ResearchConceptsExtrinsic pathwayColorectal cancer cell apoptosisIntrinsic pathwayColorectal cancer cellsImportant protective effectCancer cell apoptosisColorectal cancerCyclooxygenase-2Protective effectDifferent molecular phenotypesInduction of apoptosisTRAIL-R2Cell apoptosisTNF-R1Proapoptotic effectsDocosahexaenoicCancer cellsEicosapentaenoicAnticancer agentsApoptosisDeath receptorsMolecular phenotypesProapoptotic activityNoncancerous cellsCaspase-8 activation