2016
Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer
Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 2016, 14: 563-573. PMID: 26983689, PMCID: PMC4912439, DOI: 10.1158/1541-7786.mcr-15-0450.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorColonic NeoplasmsFemaleHCT116 CellsHeterograftsHumansMiceMice, NudeNeoplasm ProteinsProtein-Tyrosine KinasesSignal TransductionConceptsContext-specific functionsKinase-independent mannerEpithelial-mesenchymal transitionOncogenic signalingEpithelial phenotypeXenograft tumor growthCell survivalExpression of PTK6Protein tyrosine kinase 6DNA-damaging treatmentsTumor suppressor functionTyrosine kinase 6Colon cancer cellsDifferentiated epithelial cellsPTK6 knockdownTumor tissue arraysColon tumor cell linesHuman colon tumor cell linesPTK6 expressionKinase 6ERK5 activationPTK6Tumor growthDNA damageSuppressor function
1999
BRK/Sik expression in the gastrointestinal tract and in colon tumors.
Llor X, Serfas MS, Bie W, Vasioukhin V, Polonskaia M, Derry J, Abbott CM, Tyner AL. BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clinical Cancer Research 1999, 5: 1767-77. PMID: 10430081.Peer-Reviewed Original ResearchConceptsNormal gastrointestinal tractGastrointestinal tractBrk expressionColon tumorsPrimary colon tumorsCell linesAdenocarcinoma cell lineNormal epithelial cellsBRK tyrosine kinaseColon adenocarcinoma cell lineEpithelial tumorsImmunohistochemical assaysColon tumor cell linesTumor cell linesTumor samplesTractTumorsEpithelial cellsColon tumor samplesIntestinal cDNA libraryRNase protection