2014
Multiple Sporadic Colorectal Cancers Display a Unique Methylation Phenotype
Gonzalo V, Lozano JJ, Alonso-Espinaco V, Moreira L, Muñoz J, Pellisé M, Castellví-Bel S, Bessa X, Andreu M, Xicola RM, Llor X, Ruiz-Ponte C, Carracedo A, Jover R, Castells A, Balaguer F, . Multiple Sporadic Colorectal Cancers Display a Unique Methylation Phenotype. PLOS ONE 2014, 9: e91033. PMID: 24643221, PMCID: PMC3958343, DOI: 10.1371/journal.pone.0091033.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overColorectal NeoplasmsCpG IslandsDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedNeoplasms, Multiple PrimaryPhenotypeProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Ras ProteinsConceptsMultiple colorectal cancersColorectal cancerSporadic colorectal cancerMultiple tumorsCpG island methylator phenotypeSolitary tumorTumor multiplicityMismatch repair deficiency statusSynchronous colorectal cancerMethylation phenotypeCIMP-high tumorsDNA methylation profilingDNA hypermethylationBRAF mutationsDeficiency statusSignificant DNA hypermethylationTumorsTumor samplesMethylation profilingMethyLight assayTumor pairsMethylator phenotypeCpG sitesFunctional annotation clusteringPatients
2010
Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer
Gonzalo V, Lozano JJ, Muñoz J, Balaguer F, Pellisé M, de Miguel C, Andreu M, Jover R, Llor X, Giráldez MD, Ocaña T, Serradesanferm A, Alonso-Espinaco V, Jimeno M, Cuatrecasas M, Sendino O, Castellví-Bel S, Castells A, . Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer. PLOS ONE 2010, 5: e8777. PMID: 20098741, PMCID: PMC2808250, DOI: 10.1371/journal.pone.0008777.Peer-Reviewed Original ResearchConceptsSolitary tumorSporadic CRCTumor multiplicityGene promoter methylationInflammatory bowel diseaseMultiple colorectal cancersPrevention of patientsPromoter methylationLogistic regression analysisBinomial logistic regression analysisQuantitative methylation-specific PCRAberrant gene promoter methylationCancer multiplicitySolitary CRCBowel diseasePrimary CRCColorectal cancerMultiple lesionsColorectal mucosaLynch syndromeMethylation-specific PCRPolyposis syndromeKey tumor suppressor genesHereditary syndromesExclusion criteria