Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles
Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal Cancers with Microsatellite Instability Display Unique miRNA Profiles. Clinical Cancer Research 2011, 17: 6239-6249. PMID: 21844009, PMCID: PMC3186834, DOI: 10.1158/1078-0432.ccr-11-1424.Peer-Reviewed Original ResearchConceptsColorectal cancerTypes of MSIMicrosatellite instabilityMiRNA expression profilesUnique miRNA profileCRC tissuesNormal colonic mucosa tissuesSporadic MSI tumorsColonic mucosa tissuesMSS colorectal cancerLynch syndrome tumorsNormal colonic mucosaSporadic microsatellite instabilityMiRNA profilesMSI-positive samplesNormal colonic tissueUnique miRNA expression profilesExpression profilesQuantitative reverse transcriptase PCRReverse transcriptase-PCRDistinct miRNA expression profilesColonic mucosaLynch syndromeColonic tissueColorectal carcinogenesis