Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer
Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL. Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer. Molecular Cancer Research 2016, 14: 563-573. PMID: 26983689, PMCID: PMC4912439, DOI: 10.1158/1541-7786.mcr-15-0450.Peer-Reviewed Original ResearchConceptsContext-specific functionsKinase-independent mannerEpithelial-mesenchymal transitionOncogenic signalingEpithelial phenotypeXenograft tumor growthCell survivalExpression of PTK6Protein tyrosine kinase 6DNA-damaging treatmentsTumor suppressor functionTyrosine kinase 6Colon cancer cellsDifferentiated epithelial cellsPTK6 knockdownTumor tissue arraysColon tumor cell linesHuman colon tumor cell linesPTK6 expressionKinase 6ERK5 activationPTK6Tumor growthDNA damageSuppressor function