Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer
Kandimalla R, Linnekamp JF, van Hooff S, Castells A, Llor X, Andreu M, Jover R, Goel A, Medema JP. Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. Oncogenesis 2017, 6: e308-e308. PMID: 28368388, PMCID: PMC5520503, DOI: 10.1038/oncsis.2017.9.Peer-Reviewed Original ResearchConsensus molecular subtype 4Stage II colon cancerAdjuvant therapyCC patientsColon cancerRecurrence predictionWnt target gene Axin2Stage II CC patientsPoor recurrence-free survivalPoor prognosis patientsRecurrence-free survivalCpG island methylatorGene methylationPrognosis patientsCC cohortCenter cohortWorse prognosisClinical parametersPositive cancersValidation cohortMethylation-specific PCRPrognostic markerProspective mannerSubtype tumorsPrognostic biomarker