2019
Deconstructing Actin Waves
Wu M. Deconstructing Actin Waves. Structure 2019, 27: 1187-1189. PMID: 31390543, DOI: 10.1016/j.str.2019.07.010.Peer-Reviewed Original Research
2018
Membrane shape-mediated wave propagation of cortical protein dynamics
Wu Z, Su M, Tong C, Wu M, Liu J. Membrane shape-mediated wave propagation of cortical protein dynamics. Nature Communications 2018, 9: 136. PMID: 29321558, PMCID: PMC5762918, DOI: 10.1038/s41467-017-02469-1.Peer-Reviewed Original ResearchConceptsMembrane shape changesF-BAR proteinsDomain-containing proteinsPeripheral membrane proteinsProtein lateral diffusionActin machineryProtein recruitmentMembrane proteinsProtein dynamicsCortical proteinsShape changesProtein waveActin wavesUnderappreciated roleProteinMembrane undulationsLateral diffusionSpatial gradientsMachineryCytoplasmImmune cellsRecruitmentAssemblyCells
2017
Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning
Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Developmental Cell 2017, 43: 507-521.e4. PMID: 29161594, PMCID: PMC5826602, DOI: 10.1016/j.devcel.2017.10.028.Peer-Reviewed Original ResearchConceptsPlasma membraneClathrin assemblyClathrin functionEndocytic proteinsMembrane traffickingEndocytic machineryN-WASPEndocytic eventsSignal transductionDownstream factorsCell surfaceCortical patterningPattern formationAssemblyMembraneImportant insightsActive processSingle-cell patternFBP17Cdc42ClathrinEndocytosisTransductionCortical pattern formationPhosphatidylinositol
2016
Frequency and amplitude control of cortical oscillations by phosphoinositide waves
Xiong D, Xiao S, Guo S, Lin Q, Nakatsu F, Wu M. Frequency and amplitude control of cortical oscillations by phosphoinositide waves. Nature Chemical Biology 2016, 12: 159-166. PMID: 26751515, DOI: 10.1038/nchembio.2000.Peer-Reviewed Original ResearchActinsAnimalsCell Line, TumorCerebral CortexCytoskeletonInositol Polyphosphate 5-PhosphatasesKineticsLeukemia, Basophilic, AcuteLipid MetabolismMast CellsNerve Tissue ProteinsPhosphatidylinositol 3-KinasesPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphoric Monoester HydrolasesRats
2013
Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations
Wu M, Wu X, De Camilli P. Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 1339-1344. PMID: 23297209, PMCID: PMC3557052, DOI: 10.1073/pnas.1221538110.Peer-Reviewed Original ResearchConceptsPlasma membraneActin regulatory proteinsActin cytoskeletonActin dynamicsActive Cdc42Cell cortexCell physiologyRegulatory proteinsActin polymerizationDynamic spatial patternsMacromolecular assembliesCalcium oscillationsSpatial patternsActinMembraneFBP17Cdc42CellsCytoskeletonFeedback mechanismProteinPhysiologyAntigen stimulationGlobal fluctuationsMechanism
2010
Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system
Wu M, Huang B, Graham M, Raimondi A, Heuser JE, Zhuang X, De Camilli P. Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system. Nature Cell Biology 2010, 12: 902-908. PMID: 20729836, PMCID: PMC3338250, DOI: 10.1038/ncb2094.Peer-Reviewed Original ResearchActinsAcyltransferasesAdenosine TriphosphateAnimalsAntibodiesBridged Bicyclo Compounds, HeterocyclicCarrier ProteinsCattleCell LineCell MembraneCell Membrane StructuresCell-Free SystemClathrinCoated Pits, Cell-MembraneCytosolDynaminsEndocytosisFatty Acid-Binding ProteinsFibroblastsGuanosine 5'-O-(3-Thiotriphosphate)Guanosine TriphosphateHumansImaging, Three-DimensionalMiceMicroscopy, Electron, TransmissionMicroscopy, FluorescenceModels, BiologicalPotoroidaeRatsReceptors, TransferrinThiazolidines
2004
Visualization of plasma membrane compartmentalization with patterned lipid bilayers
Wu M, Holowka D, Craighead HG, Baird B. Visualization of plasma membrane compartmentalization with patterned lipid bilayers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 13798-13803. PMID: 15356342, PMCID: PMC518836, DOI: 10.1073/pnas.0403835101.Peer-Reviewed Original ResearchConceptsLipid raftsLeaflet componentsPlasma membrane compartmentalizationReceptor clustersMembrane structural organizationLipid bilayersFcepsilon receptor ITyrosine phosphorylation activityMembrane compartmentalizationLyn kinaseInner leafletPhosphorylation activityActin polymerizationCellular componentsStructural organizationCell receptorRaftsCell activationReceptor IMast cell receptorsStructural reorganizationKinaseUnique insightsBilayersProtein