2019
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress
Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. Cell Stem Cell 2019, 25: 814-829.e6. PMID: 31809739, PMCID: PMC6925542, DOI: 10.1016/j.stem.2019.11.005.Peer-Reviewed Original ResearchConceptsStem cell populationJunctional zoneOral mucosaStem cellsImportant model systemCell populationsEpithelial stem cell populationSingle-progenitor modelAsymmetric divisionLabel-retention assaysCandidate nichesSymmetric divisionTissue stressOral cavityPalatal epitheliumPhysiological stressModel systemStratified epitheliumMucosaProliferative heterogeneityEpithelium
2017
In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous
Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Archiv 2017, 470: 545-552. PMID: 28213807, PMCID: PMC5623953, DOI: 10.1007/s00428-017-2093-3.Peer-Reviewed Original ResearchConceptsSmall intestinal neuroendocrine tumorsLiver metastasesSSTR2A expressionIntestinal neuroendocrine tumorsKi67 indexNeuroendocrine tumorsPrimary tumorLiver tumorsMetastatic small intestinal neuroendocrine tumorsMore liver lesionsMost liver tumorsCorresponding liver metastasesMore liver tumorsFormalin-fixed paraffin-embedded sectionsParaffin-embedded sectionsMetastatic lesionsMetastatic tumorsSI-NETsSame patientLiver lesionsIHC scoreMetastasisScoring systemSignificant associationTumor tissue
2016
Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition
Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition. Histopathology 2016, 70: 223-231. PMID: 27560620, PMCID: PMC5921077, DOI: 10.1111/his.13068.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionColorectal carcinomaDistant metastasisImmunohistochemical evidenceEvidence of EMTAdvanced T categoryConventional colorectal carcinomaCystic nodal metastasisStage IV diseaseAdvanced local diseaseLymph node metastasisMicrosatellite instability testingBRAF V600E mutationMedian survivalMucinous featuresOverall survivalNodal metastasisNode metastasisLocal diseaseMicropapillary featuresT categoryDirty necrosisCribriform patternKRAS mutationsProminent necrosis
2010
The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma
Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. American Journal Of Pathology 2010, 177: 1514-1533. PMID: 20709804, PMCID: PMC2928982, DOI: 10.2353/ajpath.2010.100328.Peer-Reviewed Original ResearchConceptsChief cellsTranscription factor MIST1Gastric carcinogenesisMIST1 expressionSimilar progressive lossChief cell lineagesNormal oxyntic mucosaHuman gastric carcinogenesisHuman chief cellsChief cell markersIntestinal metaplasiaCell carcinomaMetaplastic lesionsResection specimensGastric adenocarcinomaPrecursor lesionsOxyntic mucosaTissue microarrayMetaplasiaMurine dataReliable markerTFF2 expressionHuman lesionsCell markersComparison of findings