2020
Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria
Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria. Modern Pathology 2020, 34: 592-602. PMID: 32958831, DOI: 10.1038/s41379-020-00676-8.Peer-Reviewed Original ResearchConceptsIdiopathic noncirrhotic portal hypertensionObliterative portal venopathyNoncirrhotic portal hypertensionPortal hypertensionLiver biopsyDiagnostic criteriaInterobserver agreement studyHistologic featuresHistopathologic diagnostic criteriaOriginal pathologic diagnosisPractical diagnostic criteriaAgreement studyKey histopathologicPortal venopathyVein sclerosisHistologic predictorsClinicopathologic correlationHistologic diagnosisPathologic diagnosisHistologic assessmentExperienced hepatopathologistsClinical informationHypertensionBiopsyThree-tiered classificationDistribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy
Huh WJ, Roland JT, Asai M, Kaji I. Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy. Biomedical Research 2020, 41: 113-118. PMID: 32307399, PMCID: PMC10037909, DOI: 10.2220/biomedres.41.113.Peer-Reviewed Original ResearchConceptsTuft cell numbersIntestinal tuft cellsTuft cellsAcute duodenitisPediatric patientsCeliac diseaseAge-matched normal controlsDouble-blind conditionsCell numberDuodenal ulcerSevere inflammationMucosal integrityPathological diagnosisDuodenal mucosaNormal controlsPathological specimensUseful markerInflammationNormal tissuesPatientsHuman intestineClinical interestPathological conditionsDuodenitisUlcers
2016
The Spectrum of Histologic Findings in Hepatic Outflow Obstruction
Gonzalez RS, Gilger MA, Huh WJ, Washington MK. The Spectrum of Histologic Findings in Hepatic Outflow Obstruction. Archives Of Pathology & Laboratory Medicine 2016, 141: 98-103. PMID: 27681331, PMCID: PMC6420777, DOI: 10.5858/arpa.2015-0388-oa.Peer-Reviewed Original ResearchConceptsHepatic outflow obstructionPortal tract changesCardiac hepatopathyBudd-Chiari syndromeOutflow obstructionHistologic findingsBudd-ChiariSinusoidal fibrosisSinusoidal dilationTract changesCentral veinHepatic venous outflow obstructionVenous outflow obstructionBile ductular reactionDistinctive histologic findingsHepatocyte dropoutDifferent pathophysiologyPrior diagnosisChronic inflammationCentrilobular necrosisDuctular reactionMorphologic findingsUndiagnosed patientsChronic natureHepatopathy