2023
SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia
Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.Peer-Reviewed Original ResearchConceptsSRY-box transcription factor 9Cell identityAdult homeostasisGastric progenitorsMucous neck cellsZymogenic chief cellsGastric developmentNeck cellsPotential genesMaster regulatorExpression patternsGene expressionSPEM cellsCell differentiationCorpus unitsSOX9 expressionSOX9Factor 9Specific expansionHomeostasisMisexpressionSox9 deletionReprogrammingChief cellsGenetic deletion
2013
Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium
Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Chronic Tamoxifen Use Is Associated with a Decreased Risk of Intestinal Metaplasia in Human Gastric Epithelium. Digestive Diseases And Sciences 2013, 59: 1244-1254. PMID: 24368421, PMCID: PMC4035390, DOI: 10.1007/s10620-013-2994-1.Peer-Reviewed Original ResearchConceptsRisk of IMTamoxifen useEndoscopic gastroduodenoscopyDecreased riskGastric cancerFemale breast cancer patientsMultivariate logistic regression analysisHuman stomachHelicobacter pylori positivityBreast cancer patientsEffect of tamoxifenLogistic regression analysisHuman gastric epitheliumClinical characteristicsPylori positivityHistopathological findingsIntestinal metaplasiaPredictive factorsSydney classificationBreast surgeryCancer patientsGastric biopsiesPremalignant lesionsEstrogen exposureBiopsy site