The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma
Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. American Journal Of Pathology 2010, 177: 1514-1533. PMID: 20709804, PMCID: PMC2928982, DOI: 10.2353/ajpath.2010.100328.Peer-Reviewed Original ResearchConceptsChief cellsTranscription factor MIST1Gastric carcinogenesisMIST1 expressionSimilar progressive lossChief cell lineagesNormal oxyntic mucosaHuman gastric carcinogenesisHuman chief cellsChief cell markersIntestinal metaplasiaCell carcinomaMetaplastic lesionsResection specimensGastric adenocarcinomaPrecursor lesionsOxyntic mucosaTissue microarrayMetaplasiaMurine dataReliable markerTFF2 expressionHuman lesionsCell markersComparison of findings