2021
The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
Ribera J, Portolés I, Córdoba-Jover B, Rodríguez-Vita J, Casals G, González-de la Presa B, Graupera M, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernández-Checa JC, Soria G, Tudela R, Esteve-Codina A, Espadas G, Sabidó E, Jiménez W, Sessa WC, Morales-Ruiz M. The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice. Communications Biology 2021, 4: 1192. PMID: 34654883, PMCID: PMC8519955, DOI: 10.1038/s42003-021-02722-w.Peer-Reviewed Original ResearchConceptsKey cellular processesIntracellular ATP productionCellular processesZebrafish embryosDownstream substratesATP biosynthesisProteome analysisMitochondrial membraneEndothelial cellsDHX15ATP productionRegulatory functionsDifferential expressionComplex IVascular regulatory functionEnergy metabolismVascular biologyTumor metastasisTherapeutical targetGene deficiencyPrimary tumor growthLower oxygen consumptionVascular physiologyDownregulation of VEGFCells
2004
Antiangiogenic therapy Creating a unique “window” of opportunity
Lin M, Sessa W. Antiangiogenic therapy Creating a unique “window” of opportunity. Cancer Cell 2004, 6: 529-531. PMID: 15607955, DOI: 10.1016/j.ccr.2004.12.003.Peer-Reviewed Original ResearchAngiogenesis InhibitorsAngiopoietin-1AnimalsAntibodies, MonoclonalBasement MembraneBlood VesselsCell MovementCollagenasesCombined Modality TherapyGamma RaysGliomaHumansMiceModels, BiologicalNeoplasmsNeovascularization, PathologicPericytesReceptor, TIE-2Time FactorsVascular Endothelial Growth Factor Receptor-2Xenograft Model Antitumor Assays