Myocardial Salvage Induced by REV-5901
Mullane K, Hatala M, Kraemer R, Sessa W, Westlin W. Myocardial Salvage Induced by REV-5901. Journal Of Cardiovascular Pharmacology 1987, 10: 398-406. PMID: 2444792, DOI: 10.1097/00005344-198710000-00004.Peer-Reviewed Original ResearchConceptsCoronary artery occlusionArtery occlusionInfarct sizeEnd-organ antagonistLeukotriene-like materialAccumulation of neutrophilsLeukotriene B4 generationSelective cyclooxygenase inhibitorsLeukotriene B4 formationSpasmogenic effectNeutrophil accumulationHemodynamic effectsHypoperfused zoneMyocardial injuryMyocardial salvageCardiac damageIschemic myocardiumB4 generationAnesthetized dogsCyclooxygenase inhibitorIschemic heartB4 formationCyclooxygenase enzymesCanine neutrophilsLipoxygenase metabolites