2022
Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes
Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes. Hepatology Communications 2022, 6: 2748-2764. PMID: 35852334, PMCID: PMC9512452, DOI: 10.1002/hep4.2042.Peer-Reviewed Original ResearchConceptsLipid raftsCaveolin-1Intact lipid raftsType 3 inositol trisphosphate receptorApical regionC-terminal amino acidsTrisphosphate receptor type 3Madin-Darby canine kidney cellsCanine kidney cellsFluorescence microscopy techniquesInositol trisphosphate receptorApical localizationTrisphosphate receptorHeavy chain 9Molecular determinantsChemical disruptionAmino acidsITPR3RaftsKidney cellsIntracellular CaFinal common eventReceptor type 3Release channelMYH9
2000
Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs
Mital S, Zhang X, Zhao G, Bernstein R, Smith C, Fulton D, Sessa W, Liao J, Hintze T. Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs. AJP Heart And Circulatory Physiology 2000, 279: h2649-h2657. PMID: 11087217, DOI: 10.1152/ajpheart.2000.279.6.h2649.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAdenosineAnimalsAnticholesteremic AgentsConsciousnessCoronary CirculationDogsEndothelium, VascularEnzyme InhibitorsGene Expression Regulation, EnzymologicHeart RateIn Vitro TechniquesMicrocirculationMyocardiumNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIINitritesNitroglycerinOxygen ConsumptionRNA, MessengerSimvastatinVasodilationVasodilator AgentsVeratrineConceptsEndothelial nitric oxide synthaseCoronary blood flowCoronary vasodilationConscious dogsSimvastatin administrationVascular endothelial nitric oxide productionVascular endothelial nitric oxide synthaseNO productionEndothelial nitric oxide productionEndothelium-independent vasodilatorCoronary vascular endotheliumShort-term administrationLipid-lowering effectsNitric oxide synthaseEndothelial NO productionMyocardial oxygen consumptionNitric oxide productionNO-dependent regulationPlasma nitrateGeneral anesthesiaENOS proteinCoronary microvesselsOxide synthaseMongrel dogsENOS mRNAQuantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR
Fulton D, Papapetropoulos A, Zhang X, Catravas J, Hintze T, Sessa W. Quantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR. AJP Heart And Circulatory Physiology 2000, 278: h658-h665. PMID: 10666099, DOI: 10.1152/ajpheart.2000.278.2.h658.Peer-Reviewed Original ResearchConceptsENOS mRNACoronary arteryCoronary microvesselsLeft ventricleENOS cDNAEndothelial nitric oxide synthase (eNOS) mRNANitric oxide synthase mRNAEndothelial cellsCanine aortic endothelial cellsRight coronary arteryENOS mRNA levelsEndothelial cell markersCompetitive PCRAortic endothelial cellsVon Willebrand factorVein endothelial cellsInducible NOSNeuronal NOSCanine vasculatureLarge arteriesCanine Left VentricleCell markersPathophysiological statesArteryCardiac vasculature
1996
Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure
Smith C, Sun D, Hoegler C, Roth B, Zhang X, Zhao G, Xu X, Kobari Y, Pritchard K, Sessa W, Hintze T. Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure. Circulation Research 1996, 78: 58-64. PMID: 8603506, DOI: 10.1161/01.res.78.1.58.Peer-Reviewed Original ResearchConceptsHeart failureCyclooxygenase-1Von Willebrand factorPacing-induced heart failureVentricular end-diastolic pressureEndothelial cellsEndothelium-dependent responsesEnd-diastolic pressureLeft ventricular pacingPeripheral blood vesselsDiastolic pressureVentricular pacingThoracic aortaClinical signsMongrel dogsWestern blottingBlood vesselsWillebrand factorArbitrary unitsEcNOSTotal RNADogsPresent studyFailureCells
1987
Myocardial Salvage Induced by REV-5901
Mullane K, Hatala M, Kraemer R, Sessa W, Westlin W. Myocardial Salvage Induced by REV-5901. Journal Of Cardiovascular Pharmacology 1987, 10: 398-406. PMID: 2444792, DOI: 10.1097/00005344-198710000-00004.Peer-Reviewed Original ResearchConceptsCoronary artery occlusionArtery occlusionInfarct sizeEnd-organ antagonistLeukotriene-like materialAccumulation of neutrophilsLeukotriene B4 generationSelective cyclooxygenase inhibitorsLeukotriene B4 formationSpasmogenic effectNeutrophil accumulationHemodynamic effectsHypoperfused zoneMyocardial injuryMyocardial salvageCardiac damageIschemic myocardiumB4 generationAnesthetized dogsCyclooxygenase inhibitorIschemic heartB4 formationCyclooxygenase enzymesCanine neutrophilsLipoxygenase metabolites