Cytochrome P450-Dependent Arachidonic Acid Metabolites, 19− and 20-Hydroxyeicosatetraenoic Acids, Enhance Sodium-Potassium ATPase Activity in Vascular Smooth Muscle
Escalante B, Sessa W, Falck JR, Yadagiri P, Schwartzman M. Cytochrome P450-Dependent Arachidonic Acid Metabolites, 19− and 20-Hydroxyeicosatetraenoic Acids, Enhance Sodium-Potassium ATPase Activity in Vascular Smooth Muscle. Journal Of Cardiovascular Pharmacology 1990, 16: 438-443. PMID: 1700215, DOI: 10.1097/00005344-199009000-00013.Peer-Reviewed Original ResearchConceptsCytochrome P450-dependent arachidonic acid metabolitesPotassium-induced relaxationArachidonic acid metabolitesAcid metabolitesOuabain-sensitive 86Rb uptakeSodium-potassium ATPase activityRat aortic ringsProstaglandin-like materialVascular smooth muscleDose-dependent fashionEffect of omegaAortic ringsSmooth muscleStimulatory effectInhibitory effectATPase activityPresent studyMetabolitesCyclooxygenaseIndomethacin